prompt1 : extract information from  breast pathology report. List the histological classification, i.e. type of cancer or DCIS, subtype, description of any necrosis, any mention of tumor infiltrating lymphocytes,  histological grade, nuclear grade,  lymphovascular invasion, calcification, receptor status, IHC and any other ancillary testing results.  List out and expand the main points.
prompt2 : The report is - Subtype Her2, Surgerv. OV. Age: : Y. Sex: F. Laboratory Patient Report. Print Date/Time: Histopathological Examination. Complete: Pre-Op Diagnosis : Right Breast Cancer. Specimens. Breast, right breast, white/lateral, black/superior. Frozen Diagnosis. : GROSS EXAMINATION: The specimen is received in a container labeled with the. name of the patient and identified as breast, right breast. The specimen consists of a simple mastectomy measuring en. bloc 15.5 x 9.5 x 3. and weighs 115 grams. There is an. anterior ellipse of skin measuring 16.5 x 7.5 cm with an. eccentric 2.7 cm areolar complex with everted nipple. Sections of nipple areola are sampled in block 1. The skin. surface shows a 4 cm long scar located near the lateral. margin and is sampled in block 2. The superficial superior. margin is inked orange and the superficial inferior margin. is inked green. The deep margin is inked black and the. specimen sectioned, showing a firm pale tan mass measuring. 4.2 x 3.7 x 2.9 cm. The mass is located in the upper inner. and lower inner quadrants. The mass grossly extends to the. inked deep margin and is 1.7 cm from the superficial. superior margin and 1.9 cm from the superficial inferior. margin. The skin overlying the mass is disrupted. Sections. of the mass are submitted in blocks 3-7. The remaining. breast is composed of yellow lobulated adipose tissue. admixed with islands of gray-white rubbery tissue. The. breast is divided into four quadrants, upper inner, lower. inner, upper outer and lower outer and sampled in blocks. 8-11 respectively. No axillary tissue is grossly. identified. Formalin fixation time is approximately 12 hours. DIAGNOSIS BASED ON GROSS AND MICROSCOPIC EXAMINATION: Breast, right simple mastectomy. - Invasive ductal carcinoma; of (breast, grade 2, extending to. within 0.4 mm of the deep margin (see cancer case summary. THIS CONFIDENTIAL AND PRIVILEGED DOCUMENT/INFORMATION IS PROTECTED BY. FEDERAL AND STATE LAW. UNAUTHORIZED DISCLOSURE, DISSEMINATION. OR DUPLICATION IS PROHIBITED. check. - Tumor present within dermis and dermal lymphatics. SPECIMEN: Total breast (including nipple and skin). PROCEDURE: Simple mastectomy. LYMPH NODE SAMPLING: No lymph nodes present. SPECIMEN INTEGRITY: Single intact specimen (margins can be. evaluated). SPECIMEN LATERALITY Right. TUMOR SITE (Invasive Carcinoma) : Upper an lower inner. quadrant. TUMOR SIZE (Invasive Carcinoma): Greatest dimension: 4.2 x 3.7 x 2.9 cm. TUMOR FOCALITY: Single focus of invasive carcinoma. MACROSCOPIC AND MICROSCOPIC EXTENT OF TUMOR: Skin: Invasive carcinoma directly invades into the. dermis without skin ulceration. Nipple: DCIS does not involve nipple epidermis. Skeletal Muscle: No skeletal muscle present. DUCTAL CARCINOMA IN SITU (DCIS) : No DCIS is present. LOBULAR CARCINOMA IN SITU (LCIS) : Not identified. HISTOLOGIC TYPE OF INVASIVE CARCINOMA: Invasive ductal. carcinoma (no special type or not otherwise specified). HISTOLOGIC GRADE: NOTTINGHAM HISTOLOGIC SCORE: Glandular (Acinar) /Tubular Differentiation: 3. Nuclear Pleomorphism: 2. Mitotic Count: 2. Overall Grade: Grade 2, score 7 (scores of 6 or 7). MARGINS: Uninvolved by invasive carcinoma. Distance of closest margin: 0.4 mm. Specify margin: Deep margin. PATHOLOGIC STAGING (pTNM) : Primary Tumor (Invasive Carcinoma) (pT) : pT2 : Tumor greater than 20 mm but < or = 50 mm. Regional Lymph Nodes (pN) : pNX: Cannot be assessed. Distant Metastasis (M) : Not applicable. ANCILLARY STUDIES: Estrogen Receptor: Performed on another specimen (TML accession #. Results: Immunoreactive tumor cells present. Quantitation: 1-2+, 10% of cells staining. Progesterone Receptor: Performed on another specimen (TML accession #. Results: No immunoreactive tumor cells present. HER2/neu: Immunoperoxidase Studies: Performed on another specimen. (TML 1. Results: Positive, score 3+. Fluorescence In Situ Hybridization (FISH) for HER2/neu: Performed on another specimen. Results: Amplified, ratio 5.90. THIS CONFIDENTIAL AND PRIVILEGED DOCUMENT/INFORMATION IS PROTECTED BY. FEDERAL AND STATE LAW. UNAUTHORIZED DISCLOSURE, DISSEMINATION. OR DUPLICATION IS PROHIBITED. MICRO' CIFICATIONS: Present in nneoplastic tissue. CLINICAL HISTORY: Palpable mass. SUMMARY OF PATHOLOGIC STAGING: pT2NXG2. Intradepartmental consultation obtained. M.D., Pathologist. , MD. THIS CONFIDENTIAL AND PRIVILEGED DOCUMEN'T/INFORMATION IS PROTECTED BY. FEDERAL AND STATE LAW. UNAUTHORIZED DISCLOSURE, DISSEMINATION. OR DUPLICATION IS PROHIBITED.

expanded version (tokens=1649) : 
 Histological classification: The invasive cancer is identified as invasive ductal carcinoma. The cancer is classified as HER2 positive subtype, which means the cancer cells have an overexpression of the human epidermal growth factor receptor 2 (HER2) protein.

Subtype: The subtype of the breast cancer is HER2 positive.

Necrosis: There is no mention of necrosis in the report.

Tumor infiltrating lymphocytes: There is no comment about tumor-infiltrating lymphocytes in the report.

Histological grade: The histological grade of the invasive carcinoma is grade 2 using the Nottingham histologic score.

Nuclear grade: The nuclear pleomorphism score is 2, which means moderate variation in the size and shape of the cancer cells.

Lymphovascular invasion: The report states that the tumor invades the dermal lymphatics.

Calcification: There is mention of microcalcifications within the neoplastic tissue.

Receptor status: The tumor tested positive for estrogen receptor with 1-2+ staining of 10% of cells and negative for progesterone receptor. The HER2/neu test came back positive with a score of 3+ and the fluorescence in situ hybridization (FISH) testing showed HER2 amplification with a ratio of 5.90.

Ancillary testing results: In addition to the receptor status tests mentioned above, FISH testing was also done on the tumor tissue to confirm HER2 amplification. The report confirms the

prompt : Please generate a succinct report in 75 words from the above information. Exclude any filler words or sentences. If something is not mentioned or specified, exclude it from the report. Low verbosity.

final output (tokens=1800) : 
 Right breast HER2 subtype invasive ductal carcinoma measuring 4.2 cm x 3.7 cm x 2.9 cm, with a histological grade of 2/3, as well as dermal tumor invasion and HER2/neu amplification. The tumor tested positive for estrogen receptor and FISH testing confirmed HER2 amplification with a ratio of 5.90. No necrosis or lymph node metastasis was found, however microcalcifications were present in the neoplastic tissue.

