prompt1 : extract information from  breast pathology report. List the histological classification, i.e. type of cancer or DCIS, subtype, description of any necrosis, any mention of tumor infiltrating lymphocytes,  histological grade, nuclear grade,  lymphovascular invasion, calcification, receptor status, IHC and any other ancillary testing results.  List out and expand the main points.
prompt2 : The report is - Subtype Basal, Pat. Surgical Pathoro. 1. CLINICAL HISTORY : Left breast mass. Locally advanced left breast Ca. GROSS EXAMINATION: A. "Breast biopsy" received and fixed. The specimen consists of a 3.1 x 2.4 x. 1.3 cm unoriented fragment of yellow-tan soft fibroadipose tissue which is. inked blue and sectioned to reveal a 1.5 x 1.0 x 1.0 cm firm white-tan ill-. defined lesion that extends to the inked surgical margin. The remainder of. the tissue consists of adipose tissue. The specimen is entirely submitted as. Block A1-A10. for Dr. ;lides to Dr. DIAGNOSIS: A. "LEFT BREAST" (INCISIONAL BIOPSY) : INVASIVE PLEOMORPHIC LOBULAR CARCINOMA. N.S.A.B.P. NUCLEAR GRADE 2 OF 3. N.S.A.B.P. HISTOLOGIC GRADE 3 OF 3. LYMPHATIC/VASCULAR INVASION: ABSENT. IN-SITU CARCINOMA: ABSENT. STATUS OF NON-NEOPLASTIC BREAST TISSUE: NOT APPLICABLE (INCISIONAL. BIOPSY) . SIZE OF BIOPSY: 3.1 x 2.4 X 1.3 CM. (DIFFUSELY INVOLVED BY INVASIVE. CARCINOMA). MICROCALCIFICATIONS: ABSENT. SURGICAL MARGIN STATUS: NOT APPLICABLE (INCISIONAL BIOPSY). ESTROGEN/PROGESTERONE RECEPTOR AND CELL CYCLE ANALYSIS: PENDING. METHODOLOGY: IMMUNOHISTOCHEMISTRY, PARAFFIN BLOCK (A5). I certify that I personally conducted the diagnostic evaluation of the above. specimen (s) and have rendered the above diagnosis (es) . M.D. ADDENDUM 1: Tissue was sent to the. for assay of the estrogen. and. progesterone receptors. The estrogen receptor activity was judged to be. negative with an estimated FMOL value of 0. The progesterone receptor activity. was judged as negative with an estimated FMOL value of 0. Please refer to. for a complete report. I certify that I personally conducted the diagnostic evaluation of the above. specimen (s) and have rendered the above diagnosis (es) . M.D. Page #. ADDENDUM 2: Immunostaining for HER2/neu (c-erbB-2) oncoprotein is performed on recut. sections of block A5. The immunostaining is done using DAKO rabbit anti-human. c-erbB-2 oncoprotein which is an affinity-isolated antibody. product. number. ) The immunostaining is performed after antigen retrieval by. heating the unstained sections at 95 degrees centigrade for 20 minutes in 10. mM citrate buffer, pH 6.0. The primary antibody is used at a dilution of. 1:3000 (manual staining), with an incubation for one hour at 37 degrees. centigrade. The Histostain Plus kit (. is used as the. detection system. Rare tumor cells exhibit barely perceptible, complete. membrane staining, but their number is too few to indicate overexpression of. HER2/neu oncoprotein. The majority of tumor tumor cells have barely. perceptible, focal membrane staining (score = 1+), indicating that the tumor. does NOT overexpress HER2/neu oncoprotein. I certify that I personally conducted the diagnostic evaluation of the above. specimen (s) and have rendered the above diagnosis (es) . M.D., , Ph.D. Pager t. 2 of 2.

expanded version (tokens=1098) : 
 Histological Classification: Invasive pleomorphic lobular carcinoma with nuclear grade 2 of 3, histologic grade 3 of 3.

Subtype: Basal

Necrosis: Not mentioned

Tumor infiltrating lymphocytes: Not mentioned

Histological Grade: 3 of 3

Nuclear Grade: 2 of 3

Lymphovascular invasion: Absent

Calcification: Microcalcifications absent

Receptor status: Negative for Estrogen and progesterone receptors

IHC: Immunostaining for HER2/neu (c-erbB-2) oncoprotein is performed and the majority of tumor cells have barely perceptible, focal membrane staining (score = 1+), indicating that the tumor does NOT overexpress HER2/neu oncoprotein.

Other ancillary testing results: None mentioned.

prompt : Please generate a succinct report in 75 words from the above information. Exclude any filler words or sentences. If something is not mentioned or specified, exclude it from the report. Low verbosity.

final output (tokens=1225) : 
 Report: The patient was diagnosed with invasive pleomorphic lobular carcinoma with basal subtype, histologic grade 3 of 3, and nuclear grade 2 of 3. There is no evidence of lymphovascular invasion or microcalcifications. Estrogen and progesterone receptors were negative and HER2/neu oncoprotein status was not overexpressed (score = 1+).

