prompt1 : extract information from  breast pathology report. List the histological classification, i.e. type of cancer or DCIS, subtype, description of any necrosis, any mention of tumor infiltrating lymphocytes,  histological grade, nuclear grade,  lymphovascular invasion, calcification, receptor status, IHC and any other ancillary testing results.  List out and expand the main points.
prompt2 : The report is - Subtype LumB, PATIENT HISTORY: CHIEF COMPLAINT/PRE-OP/POST-OP DIAGNOSIS: 1.2-cm mass upper inner quadrant left breast, core blopsy Invasive ductal. carcinoma. LMP DATE: Not provided. PROCEDURE: Left segmental mastectomy, sentinel lymph node biopsy. SPECIFIC CLINICAL QUESTION: Not provided. OUTSIDE TISSUE DIAGNOSIS: No. PRIOR MALIGNANCY: No. CHEMORADIATION THERAPY: No. OTHER DISEASES: No. ADDENDA: Addendum. Immunostains for HER-2/neu were performed on block 1B. HER2 IMNUNOHISTOCHEMISTRY: Using appropriate formalin fixed (8 - 96 hours), controls and tissue. test block, 4B5 antibody clone is used as part of FDA approved Pathway on the. and interpreted as follows: 2+. A weak to moderate complete membrane staining is. (Equivocal). observed in more than 10% of the tumor cells). NOTE: Her-2/Neu FISH was ordered and will be subsequently reported. CASE SYNOPSIS: SYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREAST. LATERALITY: Left. PROCEDURE: Segmental. Upper inner quadrant. SIZE OF TUMOR: Maximum dimension invasive component: 15 mm. MULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI: TUMOR TYPE (invasive component): Ductal adenocarcinoma, NOS. NOTTINGHAM SCORE: Nuclear grade: 2. Tubule formation: 3. Mitotic activity score: 1. Total Nottingham score: 6. Nottingham grade (1, 2, 3): 2. ANGIOLYMPHATIC INVASION: DERMAL LYMPHATIC INVASION: Not applicable. CALCIFICATION: TUMOR TYPE, IN SITU: Cribriform. Micropapillary. SURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT: LYMPH NODES EXAMINED: 4. METHOD(S) OF LYMPH NODE EXAMINATION: H/E stain. SENTINEL NODE METASTASIS: T STAGE, PATHOLOGIC: pT1c. N STAGE, PATHOLOGIC: pN1a. M STAGE: Not applicable. ESTROGEN RECEPTORS: positive, H-score: 300. PROGESTERONE RECEPTORS: positive, H-score: 225. HER2/NEU: 2+. INTERPRETATION. nuc ish(D17Z1,ERBB2)x2-6[80]. No amplification of the HER-2/NEU gene was seen by interphase FISH analysis. Fluorescence in situ hybridization (FISH) analysis was performed on a formalin-fixed Block 1B (Left segmental mastectomy 10:00). using the DNA probe for the HER-2/NEU gene. An adequate number of invasive tumor cells were. present and evaluated by four independent observers. The ratio of HER-Z/NEU signals (ERBB2) to chromosome 17 centromere. signals (. was determined to be 1.69. A ratio of greater than 2.2 is considered to be amplified with ratios of 1.80 to 2.20 in. the equivocal range; therefore, this specimen is not amplified. The average number of HER-2/NEU signals per cell was 4.10. The average number of signals for the chromosome 17 centromere was 2.43. Many of the cells exhibited 3 or more signals for. both the HER-2/NEU gene and for the chromosome 17 centromere. This may be indicative of either polyploidy or aneuploidy. for chromosome 17. Concurrent positive and negative control specimens showed the expected results. This FISH test is performed using a modification of the Vysis FDA approved PathVysion HER-2 DNA Probe Kit (1:2 LSI HER-2/neu. / CEP17 probe : T-denhyb-2 buffer). This FISH test was developed and Its performance determined by the. Pursuant to the requirements of CLIA '88, this laboratory has established and vermed the test's. accuracy and precision. FINAL DIAGNOSIS: PART 1: BREAST, LEFT, SEGMENTAL MASTECTOMY AT 10:00-. A. INVASIVE DUCTAL CARCINOMA, NOTTINGHAM GRADE 2 (TUBULAR FORMATION 3, NUCLEAR GRADE 2,. MITOTIC ACTIVITY 1; TOTAL SCORE 6/9). B. THE INVASIVE TUMOR MEASURES 1.5 CM IN LARGEST DIMENSION (GROSS MEASUREMENT). C. DUCTAL CARCINOMA IN SITU (DCIS), MICROPAPILLARY AND CRIBRIFORM PATTERNS, NUCLEAR GRADE. 2. D. DCIS ACCOUNTS FOR 6% OF TOTAL TUMOR VOLUME, ADMIXED WITH OR CLOSE TO INVASIVE. COMPONENT. E. INVASIVE TUMOR IS 2.5 MM FROM ANTERIOR MARGIN AND 4 MM FROM POSTERIOR MARGIN; DCIS IS. LESS THAN 0.2 MM FROM THE ANTERIOR MARGIN. F. NO LYMPHOVASCULAR INVASION IDENTIFIED. G. ATYPICAL DUCTAL HYPERPLASIA. H. NON-NEOPLASTIC BREAST TISSUE SHOWING PAPILLOMA, FIBROCYSTIC CHANGE AND DUCTAL. EPITHELIAL HYPERPLASIA. I. BIOPSY SITE CHANGES. J. TUMOR IS POSITIVE FOR ER AND PR, HER-2/NEU SCORE 2+ (. PART 2: ADDITIONAL ANTERIOR MARGIN, NEW ANTERIOR MARGIN, EXCISION -. BENIGN BREAST FIBROADIPOSE TISSUE. PART 3: LEFT AXILLARY SENTINEL LYMPH NODE #1, BIOPSY -. A. ONE OF TWO (1/2) LYMPH NODES, POSITIVE FOR METASTATIC CARCINOMA (SEE COMMENT). B. THE TUMOR MEASURES 1 CM. PART 4: LEFT SENTINEL LYMPH NODE #2, BIOPSY -. ONE LYMPH NODE NEGATIVE FOR METASTATIC CARCINOMA (0/1). PART 5: LEFT SENTINEL LYMPH NODE #3, BIOPSY -. ONE LYMPH NODE, NEGATIVE FOR METASTATIC CARCINOMA (0/1).

expanded version (tokens=1777) : 
 Histological classification: Invasive ductal carcinoma, Nottingham grade 2 (tubular formation 3, nuclear grade 2, mitotic activity 1; total score 6/9), ductal carcinoma in situ (DCIS), micropapillary and cribriform patterns, nuclear grade 2, and atypical ductal hyperplasia.

Subtype: LumB.

Description of necrosis: Not mentioned.

Tumor infiltrating lymphocytes: Not mentioned.

Histological grade: Nottingham grade 2.

Nuclear grade: 2.

Lymphovascular invasion: No lymphovascular invasion identified.

Calcification: Present.

Receptor status: ER and PR positive with H-score of 300 and 225 respectively. HER-2/NEU score is 2+.

IHC: Immunostains for HER-2/neu were performed on block 1B. No amplification of the HER-2/NEU gene was seen by interphase FISH analysis.

Ancillary testing results: Not applicable.

prompt : Please generate a succinct report in 75 words from the above information. Exclude any filler words or sentences. If something is not mentioned or specified, exclude it from the report. Low verbosity.

final output (tokens=1940) : 
 A 1.2 cm mass in the upper inner quadrant, left breast was diagnosed as LumB subtype of invasive ductal carcinoma with micropapillary and cribriform patterns for DCIS. With a Nottingham score of 6/9 (grade 2), atypical ductal hyperplasia was also identified. ER/PR were positive with H-scores of 300/225, HER-2/neu score was equivocal (2+). Lymphovascular invasion was not observed. One out of two axillary nodes tested positive for metastasis.

