prompt1 : extract information from  breast pathology report. List the histological classification, i.e. type of cancer or DCIS, subtype, description of any necrosis, any mention of tumor infiltrating lymphocytes,  histological grade, nuclear grade,  lymphovascular invasion, calcification, receptor status, IHC and any other ancillary testing results.  List out and expand the main points.
prompt2 : The report is - Subtype Normal, FINAL DIAGNOSIS: BREAST, LEFT, TOTAL MASTECTOMY (120.1 GRAMS) -. A. METAPLASTIC CARCINOMA OF THE BREAST, SPINDLE CELL TYPE, NOTTINGHAM GRADE II (TUBULE. FORMATION 3, NUCLEAR PLEOMORPHISM 3, MITOTIC ACTIVITY 1; TOTAL SCORE 7/9). B. THE INVASIVE TUMOR MEASURES 3.8 CM IN GREATEST DIMENSION. C. NO LYMPHOVASCULAR SPACE INVASION IS NOTED. D. INKED MARGINS ARE NEGATIVE FOR CARCINOMA; HOWEVER, A FOCUS OF INVASIVE CARCINOMA IS LESS. THAN 1.0 MM (LESS THAN 0.1 CM) FROM THE ANTERIOR INKED MARGIN. E. THE INVASIVE CARCINOMA IS LOCATED IN THE CENTRAL AREA. F. THE NIPPLE DERMIS AND ADJACENT SKIN DERMIS, BUT NOT THE EPIDERMIS, ARE INVOLVED BY INVASIVE. CARCINOMA. G. NIPPLE DUCTS WITH SQUAMOUS METAPLASIA. H. PREVIOUS BIOPSY SITE CHANGES. I. THE INVASIVE TUMOR CELLS ARE NEGATIVE FOR ESTROGEN RECEPTOR, WEAKLY POSITIVE FOR. PROGESTERONE RECEPTOR, AND NEGATIVE FOR HER-2, AS PER PREVIOUS PATHOLOGY REPORT. (see comment). J. NON-NEOPLASTIC BREAST WITH RADIAL SCARS. COMMENT: Due to the weakly positive PR result on the core biopsy based on stains performed at. hormone. receptor immunohistochemistry will be repeated and an addendum will follow. Addendum. BREAST TUMOR IMMUNOHISTOLOGY RESULTS. HORMONE RECEPTOR IMMUNOHISTOCHEMISTRY. H SCORE. RAW IMMUNOSTAINING SEMIQUANTITATION. ER: Weakly positive. 10. (0: 91%; 1+: 8%; 2+: 1%; 3+: 0%). PR: Negative. o. (0: 100%; 1+: 0%; 2+: 08; 3+:0%). ESTROGEN/PROGESTERONE RECEPTORS (ER/PR) TEST DETAILS: Using formalin fixed tissues (8-96 hours) and appropriate. positive and negative internal/external controls; the test for the presence of hormone receptor protein is performed by the. immunoperoxidase method according to the ASCO-CAP Guidelines. A positive Estrogen or Progesterane receptor tumor shows. nuclear immunostaining in greater than or equal to 1% of the tumor cells (i.e. and H-score of 1 or higher). The ER and PR. Histologic Score (H-Score, or HS) is calculated as the sum of intensity of staining times the proportion of cells staining and has a. dynamic range of 0 to 300. The semiquantitation immunostaining raw data used to calculate the H-score is also shown above in. the report. Generally, the H-score correlates to percentage of positive cells. According to. the correlation of mean H-score versus percent cells staining for ER is as follows: H-score of 251 (>75% cells staining); H-. score of 130 (51-75% cells staining); H-score of 42 (10-50% cells staining); H-score of 4 (<10% cells staining). Estrogen receptor antibody SP1, an IVD, is performed using the. Progesterone receptor antibody 1E2, an IVD, is performed using the. CASE SYNOPSIS: SYNOPTIC - PRIMARY INVASIVE CARCINOMA OF BREAST. LATERALITY: Left. PROCEDURE: Simple mastectomy. Central subareolar. SIZE OF TUMOR: Maximum dimension invasive component: 38 mm. MULTICENTRICITY/MULTIFOCALITY OF INVASIVE FOCI: TUMOR TYPE (invasive component): Metaplastic carcinoma. NOTTINGHAM SCORE: Nuclear grade: 3. Tubule formation: 3. Mitotic activity score: 1. Total Nottingham score: 7. Nottingham grade (1, 2, 3): 2. ANGIOLYMPHATIC INVASION: DERMALLYMPHATIC INVASION: CALCIFICATION: SURGICAL MARGINS INVOLVED BY INVASIVE COMPONENT: Distance of invasive tumor to closest margin: 1 mm. PAGET'S DISEASE OF NIPPLE: LYMPH NODES EXAMINED: 0. METHOD(S) OF LYMPH NODE EXAMINATION: Other: None. SKIN INVOLVED (ULCERATION): T STAGE, PATHOLOGIC: pT2. N STAGE, PATHOLOGIC: pNX. M STAGE: Not applicable. ESTROGEN RECEPTORS: negative. PROGESTERONE RECEPTORS: positive, H-score: 60. HER2/NEU: 0. MICROSCOPIC: Block 1B: Antibody/Antigen. Vimentin. Positive. S-100. Rare weakly positive cells. CK5. Positive. AE1/AE3. Weakly positive. CK17. Positive. P63. Positive. CK14. Positive. Block 1C: Antibody/Antigen. P63. Highlights tumor cells and myoepithelial cells. Smooth muscle myosin heavy chain Highlights myoepithelial cells. Utilizing formalin-fixed (8-96 hour range), paraffin embedded tissue, immunohistology is. performed with the following selected antibodies and designated antibody clone (s), directed. against the following antigenic target (s), with adequate positive and negative internal and. external controls. Antibodies are optimized appropriate for fixation times. ANTIBODY. CLONE. TARGET ANTIGEN. VENDOR. Vimentin. V9. Mesenchymal cells. S-100. Polyclonal Rabbit. Melanoma screen. CK 5. XM26. High molec wt keratin. AE1/AE3. AE1/AE3. carcinomas. CK 17. E3. High molec wt keratin. p63. 4A4. Myoepithelial cells. CK 14. LL002. High molec wt keratin. Myosin. SMMS-1. Myoepithelial cells.

expanded version (tokens=1814) : 
 Based on the breast pathology report, the following findings can be extracted and expanded:

1. Histological Classification: Metaplastic Carcinoma of the breast, spindle cell type with a Nottingham grade II (tubule formation 3, nuclear pleomorphism 3, mitotic activity 1; total score 7/9).

2. Tumor Size: The invasive tumor measures 3.8 cm in the greatest dimension.

3. Lymphovascular Invasion: No lymphovascular space invasion is noted.

4. Margins: Inked margins are negative for carcinoma; however, a focus of invasive carcinoma is less than 1.0 mm (less than 0.1 cm) from the anterior inked margin.

5. Location: The invasive carcinoma is located in the central area.

6. Involvement: The nipple dermis and adjacent skin dermis, but not the epidermis, are involved by invasive carcinoma. Nipple ducts with squamous metaplasia. The non-neoplastic breast with radial scars.

7. Nuclear Grade: Nottingham score of nuclear grade 3

8. Hormone Receptor Status: The invasive tumor cells are negative for estrogen receptor, weakly positive for progesterone receptor as per previous pathology report. H-score for PR = 60. Due to the weakly positive PR result on the core biopsy based on stains performed, hormone receptor immunohistochemistry will be repeated.

9. Ancillary testing results

prompt : Please generate a succinct report in 75 words from the above information. Exclude any filler words or sentences. If something is not mentioned or specified, exclude it from the report. Low verbosity.

final output (tokens=1977) : 
 Left breast total mastectomy (120.1g) revealed a 3.8cm central invasive metaplastic carcinoma of spindle cell type with Nottingham grade II (tubule formation 3, nuclear pleomorphism 3, mitotic activity 1; total score 7/9). Lymphovascular invasion absent. Inked margins negative for carcinoma, however, a focus <1mm from the anterior margin. Nipple and adjacent skin dermis involved by invasive carcinoma. Hormone receptor negative for ER and weakly positive for PR as per previous report.

