prompt1 : extract information from  breast pathology report. List the histological classification, i.e. type of cancer or DCIS, subtype, description of any necrosis, any mention of tumor infiltrating lymphocytes,  histological grade, nuclear grade,  lymphovascular invasion, calcification, receptor status, IHC and any other ancillary testing results.  List out and expand the main points.
prompt2 : The report is - Subtype LumA, SPECIMENS: A. SENTINEL NODE #1 AND #2. B. RIGHT BREAST. C. RIGHT AXILLARY CONTENTS. SPECIMEN(S): A. SENTINEL NODE #1 AND #2. B. RIGHT BREAST. C. RIGHT AXILLARY CONTENTS. GROSS DESCRIPTION: A. SENTINEL NODE #1 AND #2. Received fresh labeled with the patient's identification and "sentinel node #1 and #2, right axilla" is a 1.8. x 1.5 x 0.6 cm portion of adipose tissue, within which, two lymph nodes are identified, 0.4 cm( #2) and. 0.8 cm( #1). A touch preparation is made on each node. The specimen is entirely submitted as follows: A1- lymph node #1. A2-lymph node #2. B. RIGHT BREAST. Received fresh labeled with the patient's identification and designated "right breast" is an oriented. (suture in axilla), 358 g, 21 x 17 x 5 cm mastectomy specimen with 7.5 x 5.4 cm beige skin ellipse. showing a 1 cm diameter retracted nipple. Ink code: Posterior-deep, anterior/superior-blue,. anterior/inferior-orange. The specimen is serially sectioned from lateral to medial into 13 slices. revealing two possible lesions. Mass #1, in the upper inner quadrant (two o'clock, slices 9-10), 2 x 1.5 x. 1.4 cm, is located 2.2-cm from the deep margin and 1.4-cm from anterior. Approximately 4.5-cm from. mass #1, a second mass is demonstrated in the upper outer quadrant (slice 8), 2 x 1.5 x 1 cm, located. 2.5-cm from the deep margin and 1 cm from anterior. A portion of the specimen is submitted for tissue. procurement (mass #1). Representatively submitted: B1-B2: Nipple. B3: Skin. B4-B5: Mass #1, two o'clock, UIQ, slice 9. B6-B7: Mass #1, two o'clock, UIQ, slice 9. B8: Deep margin overlying mass #1, slice 9. B9: Firm tissue adjacent to mass #1, slice 9. B10-B12: Mass #2, UOQ, slice 8. B13: Deep margin, mass #2, slice 8. B14: Representative section, LOQ, slice 6. B15-B16: Representative sections, LIQ, slice 12. B17: Possible axillary lymph nodes. C. RIGHT AXILLARY CONTENTS. Received fresh labeled with the patient's identification and " axillary contents" is a 10.5 x 10.0 x 2.5 cm. portion of adipose tissue, within which, 34 possible lymph nodes are identified, ranging from 0.1 to 2.5. cm. The cut surfaces of the larger nodes are fatty to soft tan-pink. No evidence of tumor is grossly. noted. The specimen is entirely submitted as follows: C1-six lymph nodes. C2-six lymph nodes. C3-six lymph nodes. C4-six lymph nodes. C5-seven lymph nodes. C6-one lymph node bisected. C7-one lymph node bisected. C8-C9-one lymph node. C10-C14-remaining soft tissue. DIAGNOSIS: A. LYMPH NODE, SENTINEL #1 and #2, RIGHT AXILLA, EXCISION: - METASTATIC CARCINOMA TO ONE OF ONE LYMPH NODE (1/1),. MEASURING 8-MM WITH EXTRANODAL EXTENSION. B. BREAST, RIGHT, MASTECTOMY: - INVASIVE DUCTAL CARCINOMA, SBR GRADE 2, MEASURING 1.1 CM, PRESENT IN UPPER. INNER QUADRANT. - HIGH NUCLEAR GRADE, DUCTAL CARCINOMA IN SITU, SOLID type. - SURGICAL RESECTION MARGINS NEGATIVE FOR TUMOR. BIOPSY SITE CHANGES WITH FIBROSIS, GRANULATION TISSUE. - usual ductal hyperplasia without atypia. - fibroadenoma (0/.7-CM) AND INTRADUCTAL PAPILLOMA (0.2-CM). SEE SYNOPTIC REPORT. C. LYMPH NODES, RIGHT, AXILLARY DISSECTION: - Thirty-FOUR LYMPH NODES, NEGATIVE FOR METASTASES (0/34). NOTE: Two nodules are grossly identified, one located in the upper inner quadrant and one located in. the upper outer quadrant. Microscopically, the former is invasive ductal carcinoma and the later is. fibroadenoma. SYNOPTIC REPORT - BREAST. Specimen Type: Mastectomy. Needle Localization: No. Laterality: Right. Invasive Tumor: Present. Multifocality: No. WHO CLASSIFICATION. Invasive ductal carcinoma, NOS 8500/3. Tumor size: 1.1cm. Tumor Site: Upper inner quadrant. Margins: Negative. Tubular Score: 3. Nuclear Grade: 2. Mitotic Score: 2. Modified Scarff Bloom Richardson Grade: 2. Necrosis: Absent. Vascular/Lymphatic Invasion: None identified. Lobular neoplasia: None. Lymph nodes: Sentinel lymph node and axillary dissection. Lymph node status: Positive 1 /35 Extranodal extension. Micrometastases: DCIS present. Margins uninvolved by DCIS. DCIS Quantity: Estimate 5%. DCIS Type: Solid. DCIS Location: Associated with invasive tumor. Nuclear grade: High. Necrosis: Absent. ER/PR/HER2 Results. ER: Positive. PR: Positive. HER2: Negative by FISH. Performed on Case: Pathological staging (pTN): pT 1c N 1a. CLINICAL HISTORY: year old with right breast cancer, previous biopsy. PRE-OPERATIVE DIAGNOSIS: None given. INTRAOPERATIVE CONSULTATION. TPA: Positive for carcinoma. Called by Dr. to Dr at. Right breast, gross examination: Two possible lesions, mass number one, 1.5-cm located 3.2-cm from. deep margin and 1.4-cm from anterior, mass number two, 2-cm in size located 2.5-cm from deep and. 1cm from anterior. Diagnosis called at. by Dr. ADDENDUM: PathVysion HER-2 DNA Probe Kit. Case oAnalytical Interpretation of Results: HER-2 NOT AMPLIFIED. Clinical Interpretation of results. Amplification of the HER-2 gene was evaluated with interphase fluorescence in-situ. hybridization (FISH) on formalin-fixed paraffin embedded tissue sections using a chromosome. 17 centromeric probe and a HER-2 probe that spans the entire HER-2 gene in the. by Dr.. A majority of tumors cells displayed 2 chromosome 17. signals and 2 HER-2 signals, with a HER-2/CEP 17 Ratio </=2.0, consistent with no. amplification of the HER2/neu gene. Block used B7. Source of case: Tissue fixation. formalin-fixed tissue. Outside Case No: NA. Tissue source. breast Results interpreted: HER2/CEP17 ratio: 1.15. This ratio is derived by dividing the total number of LSI HER-2/neu signals by the total number of. CEP17 signals in at least 20 interphase nuclei with nonoverlapping nuclei in the neoplastic. mammary epithelial cells. Cells with no signals or with signals of only one color are disregarded. Method of ratio enumeration: manual count. Limitations. The Vysis PathVysion Kit is not intended for use to screen for or diagnose breast cancer. It is. intended to be used as an adjunct to other prognostic factors currently used to predict disease-free. and overall survival in stage II, node-positive breast cancer patients. In making decisions regarding. adjuvant CAF treatment, all other available clinical information should also be taken into. consideration, such as tumor size, number of involved lymph nodes, and steroid receptor status. treatment decision for stage II, node-positive breast cancer patients should be based on HER-. 2/neu. gene amplification status alone. Overview of this test. FDA APPROVED REAGENT. PathVysion HER-2 DNA Probe Kit is FDA approved for selection of. natients for whom Herceptin therapy is being considered. These tests were performed in the. under the direction. of Dr.. The results of these studies should always be interpreted in the context of the. clinical, morphological, and immunophenotypic diagnosis. Microscopic/Diagnostic Dictation:,. Microscopic/Diagnostic Dictation: Final Review:,. Microscopic/Diagnostic Dictation:, I. Final Review: Pathologist,. Final: Pathologist. Addendum:. Pathologist,. Addendum Final: Pathologist.

expanded version (tokens=2411) : 
 Histological classification: 

- Invasive ductal carcinoma, SBR grade 2 
- High nuclear grade, ductal carcinoma in situ (DCIS), solid type 
- Fibroadenoma 
- Intraductal papilloma 

Subtype: Luminal A 

Description of tumor: 

- Two possible lesions were identified in the upper inner and outer quadrants of the right breast and were submitted for tissue procurement (mass #1 and mass #2) 
- Mass #1 measured 2 x 1.5 x 1.4 cm and was located 2.2 cm from the deep margin and 1.4 cm from anterior 
- Mass #2 measured 2 x 1.5 x 1 cm and was located 2.5 cm from the deep margin and 1 cm from anterior 
- Surgical resection margins were negative for tumor 

Necrosis: Absent 

Tumor infiltrating lymphocytes: Not mentioned 

Histological grade: SBR grade 2 

Nuclear grade: High 

Lymphovascular invasion: None identified 

Calcification: Not mentioned 

Receptor status: 

- ER: Positive 
- PR: Positive 
- HER2: Negative by FISH 

Ancillary testing results: 

- PathVysion HER-2 DNA Probe Kit: HER-2 not amplified with a HER2/CEP17 ratio of 1.15 

It should be noted that the report also mentions the

prompt : Please generate a succinct report in 75 words from the above information. Exclude any filler words or sentences. If something is not mentioned or specified, exclude it from the report. Low verbosity.

final output (tokens=2580) : 
 A  year-old female with right breast cancer underwent a mastectomy and axillary dissection. Histological examination revealed invasive ductal carcinoma, SBR grade 2 in the upper inner quadrant, accompanied by high nuclear grade DCIS and fibroadenoma. Lymph nodes sent for evaluation showed metastatic carcinoma in one out of one lymph node with extranodal extension. Her tumor was Luminal A subtype, ER/PR-positive and HER2-negative by FISH; HER-2 DNA Probe Kit confirmed non-amplification of the HER2 gene. Surgical resection margins were negative for tumor.

