prompt1 : extract information from  breast pathology report. List the histological classification, i.e. type of cancer or DCIS, subtype, description of any necrosis, any mention of tumor infiltrating lymphocytes,  histological grade, nuclear grade,  lymphovascular invasion, calcification, receptor status, IHC and any other ancillary testing results.  List out and expand the main points.
prompt2 : The report is - Subtype Her2, SPECIMENS: A. WLE RIGHT BREAST. B. RIGHT AXILLARY CONTENTS. SPECIMEN(S): A. WLE RIGHT BREAST. B. RIGHT AXILLARY CONTENTS. INTRAOPERATIVE CONSULTATION DIAGNOSIS: Part A, WLE Right breast, gross examination: Tumor 0.2-cm from posterior margin. Called to Dr. at. by Dr. GROSS DESCRIPTION: A. WLE RIGHT BREAST. Received fresh labeled with matching patient identifiers is an oriented (short-superior, long-lateral) 124. g, 9.7 (medial to lateral) x 9 x 3 cm lumpectomy with a slender fragment of tan skin 2.8 x 0.3 cm. The. specimen is inked as follows: anterior - blue, posterior - black, superior - red, inferior - orange, medial. green, lateral - yellow. The specimen is serially sectioned from medial to lateral into 7 slices revealing. a 2.8 x 2.5 x 1.4 cm ill defined firm tan mass approaching the closest posterior margin at 0.2 cm, and. superior margin at 0.5 cm. A portion of the specimen is submitted for tissue procurement. Representative sections are submitted as follows: A1-A2: Perpendicular sections medial margin. A3-A4: Section 2 anterior. A5: Section 2 posterior. A6: Section 3 inferior. A7: Section 3 anterior/superior. A8-A9: Section 3 superior. A10-A11: Section 4 lesion and posterior. A12: Section 4 anterior/inferior. A13-A16: Section 5, lesion and nearest posterior. A17-A18: Section 6, lesion and posterior/anterior. A19-A20: Section 6, lesion and superior. A21-A22: Perpendicular sections lateral margin. A23-A26: Medial margin. A27: Section 6, inferior aspect. A28: Lateral margin. A29: Lateral margin. A30: Section 5, superior margin. A31: Section 2, superior aspect. A32: Section 2, inferior aspect. A33: Section 5, inferior margin. A34: Section 2, superior aspect. B. RIGHT AXILLARY CONTENTS. Received in formalin in a container labeled with matching patient identifiers is a portion of red yellow. fibroadipose tissue measuring 10.7 x 5.9 x 2.5 cm. Multiple possible lymph nodes are identified ranging. in size from 0.3 x 0.3 x 0.3 up to 4 x 3.5 x 2 cm. Cassette summary: B1-B3: Representative sections, largest lymph node. B4: Two possible lymph nodes. B5: Two possible lymph nodes. B6: Four possible lymph nodes. B7: Four possible lymph nodes. B8: Two possible lymph nodes. B9: Two possible lymph nodes. B10: Three possible lymph nodes. B11-B15: Additional possible lymph nodes. DIAGNOSIS: A. BREAST, RIGHT, WIDE LOCAL EXCISION: - INVASIVE DUCTAL CARCINOMA, POORLY DIFFERENTIATED. (SBR GRADE 3), WITH APOCRINE FEATURES, AND SEVERAL FOCI OF. MICROINVASION ASSOCIATED WITH DCIS. - TUMOR MEASURES AT LEAST 3 CM IN GREATEST DIMENSION. INVASIVE CARCINOMA IS 2 MM FROM THE DEEP MARGIN. - EXTENSIVE LYMPHVASCULAR INVASION IS PRESENT. DUCTAL CARCINOMA IN SITU (DCIS), SOLID TYPE, NUCLEAR GRADE 3,. WITH NECROSIS AND ASSOCIATED LYMPHOID INFILTRATE, INVOLVING. LOBULES. DCIS IS PRESENT AT THE LATERAL MARGIN, IS WITHIN 1 MM OF THE. ANTERIOR/MEDIAL AND ANTERIOR MARGIN, AND IS WITHIN 2 MM. OF THE DEEP MARGIN. B. AXILLARY CONTENTS, RIGHT, DISSECTION: - METASTATIC CARCINOMA TO 2 OF 25 LYMPH NODES WITH LARGEST. METASTASIS MEASURING 4 CM (2/25). - NO EXTRACAPSULAR EXTENSION IS SEEN. SYNOPTIC REPORT - BREAST. Specimen Type: Excision. Needle Localization: Laterality: Right. Invasive Tumor. Present. Multifocality: Yes. WHO CLASSIFICATION. Invasive ductal carcinoma, NOS 8500/3. Tumor size: 3cm. Tumor Site: Upper outer quadrant. Margins: Negative. Distance from closest margin: deep. Tubular Score: 3. Nuclear Grade: 3. Mitotic Score: 2. Modified Scarff Bloom Richardson Grade: 3. Necrosis: Absent. Vascular/Lymphatic Invasion: Present. Lobular neoplasia: None. Lymph nodes: Axillary dissection. Lymph node status: Positive 2/25. DCIS present. Margins involved by DCIS: lateral margin. DCIS Quantity: Estimate 25%. DCIS Type: Solid. DCIS Location: Both associated and separate from invasive tumor mass. Nuclear grade: High. Necrosis: Present. ER/PR/HER2 Results. ER: Negative. PR: Negative. HER2: Positive by IHC. Performed on. Case: This case - the largest lymph node with metastasis. Pathological staging (pTN): pT 2N1. SYNOPTIC REPORT - BREAST, ER/PR RESULTS. Specimen: Surgical Excision. Block Number: B2 (Lymph node with metastasis). ER: Negative. Allred Score: 0 = Proportion Score 0 + Intensity Score 0. PR: Negative. Allred Score: 0 = Proportion Score 0 + Intensity Score 0. COMMENT: The Allred score for estrogen and progesterone receptors is calculated by adding the sum of the. proportion score (0 = no staining, 1 = <1% of cells staining, 2 = 1 - 10% of cells staining, 3 = 11-30% of. cells staining, 4 = 31-60% of cells staining, 5 = >60% of cells staining) to the intensity score (1 = weak. intensity of staining, 2 = intermediate intensity of staining, 3 = strong intensity of staining), with a scoring. range from 0 to 8. ER/PR positive is defined as an Allred score of >2 and ER/PR negative is defined as an Allred score. of less than or equal to 2. METHODOLOGY: Tissue was fixed in 10% neutral buffered formalin for no less than 8 and no longer than 24 hours. Immunohistochemistry was performed usina the mouse anti-human ER (ER 1D5, 1:100) and PR (PGR. 136, 1:100) provided by. following the manufacturer s instructions. This. assay was not modified. Interpretation of the ER/PR immunohistochemical stain is guided by published. results in the medical literature, information provided by the reagent manufacturer and by internal. review of staining performance. SYNOPTIC REPORT - BREAST HER-2 RESULTS. Specimen: Surgical Excision. Block Number: B2 (Lymph node with metastasis). Interpretation: POSITIVE. Intensity: 3+. % Tumor Staining: 100%. Fish Ordered: METHODOLOGY: Tissue was fixed in 10% neutral buffered formalin for no less than 8 and no longer than 24 hours. Her2 analysis was performed using the FDA approved. HercepTest (TM) test kit. using rabbit anti-human HER2. This assay was not modified. External kit-slides. provided by the manufacturer (cell lines with high, low and negative HER2 protein expression) and in-. house known HER2 amplified control tissue were evaluated along with the test tissue. Adequate, well. preserved, clear-cut invasive carcinoma was identified for HER2 evaluation. Interpretation of the HER2. immunohistochemical stain is guided by published results in the medical literature, information provided. by the reagent manufacturer and by internal review of staining performance. This assay has been validated according to the 2007 joint recommendations and guidelines from. ASCO and CAP and from the NCCN HER2 testing in Breast Cancer Task Force. Pathology. Department takes full responsibility for this test's performance. CLINICAL HISTORY: :year-old woman, right breast, upper outer 4 cm mass, IDC, ER/PR negative; HER-2/neu positive,. with palpable adenopathy, here for lumpectomy and axillary lymph node dissection. PRE-OPERATIVE DIAGNOSIS: Right breast cancer. Microscopic/Diagnostic Dictation; Pathologist,. Final Review: Pathologist,. Final Review: Pathologist,. Final: Pathologist.

expanded version (tokens=2365) : 
 Histological classification:

- Invasive ductal carcinoma, poorly differentiated, with apocrine features, and several foci of microinvasion associated with DCIS.
- Ductal carcinoma in situ (DCIS), solid type, nuclear grade 3, with necrosis and associated lymphoid infiltrate.

Subtype: HER2-positive

Description of any necrosis: Necrosis is present in the DCIS.

Mention of tumor infiltrating lymphocytes: There is associated lymphoid infiltrate in the DCIS.

Histological grade:

- Invasive ductal carcinoma: SBR grade 3
- Nuclear grade: 3
- Mitotic score: 2
- Modified Scarff Bloom Richardson grade: 3

Lymphovascular invasion: Extensive lymphovascular invasion is present.

Calcification: Not mentioned in the report.

Receptor status:

- ER: Negative
- PR: Negative
- HER2: Positive by IHC

IHC and other ancillary testing results:

- The Allred score for ER and PR is 0, indicating negative staining for both receptors.
- HER2 immunohistochemical stain is 3+, with 100% tumor staining, indicating HER2 positivity.
- Fish was ordered but the results are not mentioned in the report. 

Overall, the report suggests a poorly differentiated HER2-positive invasive ductal carcinoma measuring at least 3 cm in the right breast with several foci of microinvasion associated with necrotic

prompt : Please generate a succinct report in 75 words from the above information. Exclude any filler words or sentences. If something is not mentioned or specified, exclude it from the report. Low verbosity.

final output (tokens=2523) : 
 A poorly differentiated HER2-positive invasive ductal carcinoma with several foci of microinvasion associated with necrosis and lymphovascular invasion was detected in a right breast lumpectomy specimen measuring at least 3 cm. There was also ductal carcinoma in situ (DCIS) present, solid type, nuclear grade 3, associated lymphoid infiltrate and necrosis. Axillary dissection revealed metastatic carcinoma to 2 out of 25 lymph nodes tested. ER and PR receptors were negative, while HER2 was positive by IHC.

