prompt1 : extract information from  breast pathology report. List the histological classification, i.e. type of cancer or DCIS, subtype, description of any necrosis, any mention of tumor infiltrating lymphocytes,  histological grade, nuclear grade,  lymphovascular invasion, calcification, receptor status, IHC and any other ancillary testing results.  List out and expand the main points.
prompt2 : The report is - Subtype Basal, ACC # 26. A) ADDITIONAL MARGIN OF MOST MEDIAL TUMOR, EXCISION: Benign breast tissue, no tumor present. (B). LEFT BREAST, SEGMENTAL MASTECTOMY: MULTIFOCAL INVASIVE DUCTAL CARCINOMA WITH ASSOCIATED LYMPHOCYTIC. INFILTRATE, HIGH NUCLEAR GRADE, NOTTINGHAM HISTOLOGIC GRADE. 3. (SEE COMMENT). LARGEST FOCUS OF INVASIVE CARCINOMA MEASURES 1.2 CM IN GREATEST. DIMENSION IN THE MEDIAL ASPECT OF THE SPECIMEN. MULTIPLE SATELLITE FOCI OF INVASIVE CARCINOMA ARE LATERAL TO THE. MAIN FOCUS AND MEASURE 5 MM (X 2), 4 MM, 3 MM AND 1 MM. LYMPHOVASCULAR INVASION IDENTIFIED. DUCTAL CARCINOMA IN SITU (DCIS), HIGH GRADE, PREDOMINANTLY. CRIBRIFORM AND CLINGING TYPES WITH CANCERIZATION OF LOBULES. AND ASSOCIATED LYMPHOCYTIC INFILTRATE. DCIS EXTENDS IN AN APPARENT IRREGULAR DISTRIBUTION OVER A 4 CM AREA. DCIS EXTENDS TO LESS THAN 1 MM FROM THE ANTERIOR MARGIN, TO 1 MM. FROM THE INFERIOR MARGIN, AND TO 2 MM FROM THE SUPERIOR AND. POSTERIOR MARGINS. INVASIVE CARCINOMA EXTENDS TO 2 MM FROM THE ANTERIOR MARGIN. (SEE. COMMENT). (C) ADDITIONAL CENTRAL ANTERIOR INFERIOR MARGIN, EXCISION: Benign breast tissue, no tumor present. (D) LEFT AXILLARY CONTENTS, DISSECTION: METASTATIC CARCINOMA IN ONE OF THIRTY LYMPH NODES (1/30); METASTASIS. MEASURES 7 MM; NO EXTRANODAL EXTENSION IDENTIFIED. (E) ADDITIONAL LEVEL I LEFT AXILLARY TISSUE, EXCISION: Two lymph nodes, no tumor present (0/2). Entire report and diagnosis completed by. COMMENT. Additional tissue was re-excised, and invasive carcinoma does not approach the final margins. However, I. with involvement of lobules is 1 mm from the final inferior margin and 2 mm from. the final superior and posterior margins. Tumor marker studies will be performed and reported in an addendum. GROSS DESCRIPTION. (A) ADDITIONAL MARGIN OF MOST MEDIAL TUMOR - Received is a piece of fibroadipose. tissue (1.8 x 1.2 x 0.5 cm) with clips on the true margin. The true margin inked black. The. specimen is serially sectioned and entirely submitted in A. (B) LEFT SEGMENTAL MASTECTOMY - A segmental mastectomy specimen (8.0 x 6.5 X 5.5. cm) with a short stitch at the superior aspect, long stitch at the lateral aspect, and multiple clips. on the anterior aspect. The specimen is serially sliced from medial to lateral into 11 slices. A. well-circumscribed tan-pink tumor 1.4 x 1.1 x 1.0 cm, with an associated biopsy clip is identified in. slice #3, which is 0.7 cm from the closest anterior margin. Multiple smaller nodules are identified. lateral to the main tumor. One of these is very close to the anterior margin in the central anterior. inferior aspect of the specimen, and additional tissue is requested from this margin. INK CODE: Anterior - yellow, posterior - black, superior - blue, inferior - green, medial. and lateral - red. SECTION CODE: B1, medial perpendicular margin; B2, tissue adjacent to tumor from. slice #2 ; B3-B7, tumor and margins from slice #3 (B3 and B4, tumor with anterior margin in area. of clip; B5, inferior margin; B6, posterior margin; B7, superior margin); B8, fibrous tissue adjacent. to the tumor from slice #4; B9, one small nodule, 1.2 cm from superior margin and 1.8 from. anterior margin of slice #4; B10, one small nodule 1.0 cm from anterior margin and 1.2 cm from. superior margin of slice #5; B11, one small nodule, 1.5 cm from anterior margin, 2.0 cm from. superior margin of slice #5; B12, B13, one small nodule, 0.1 cm from anterior margin and 1.2 cm. from inferior margin of slices #6 and #7; B14, one small nodule 0.4 cm from posterior margin and. 1.5 cm from inferior margin of slice #4; B15-818, remainder of margins of slice #4, entirely. submitted (B15, anterior margin; B16, superior margin; B17, posterior margin; B18, inferior. margin); B19, representative section from slice #8; B20, lateral perpendicular margin. (C) ADDITIONAL CENTRAL ANTERIOR INFERIOR MARGIN, LEFT BREAST - A portion of. fibroadipose tissue (2.0 x 1.3 x 0.5 cm) with clips on the true margin. The true margin is inked. black. The specimen is serially sectioned and entirely submitted in C1-C2. (D) LEFT AXILLARY CONTENTS - Adipose tissue (11.0 x 7.5 x 3.0 cm). Multiple lymph nodes. are identified ranging from 0.2 x 0.2 x 0.2 cm to 2.5 x 1.5 x 0.8 cm. SECTION CODE: D1-D3, each containing six lymph nodes; D4, four lymph nodes; D5,. four. lymph nodes; D6, one lymph node, trisected; D7, one lymph node, serially sectioned: n8. one lymph node, serially sectioned; D9 and D10, one lymph node, serially sectioned. (E) ADDITIONAL LEVEL I LEFT AXILLARY TISSUE - Two lymph nodes (0.2 x 0.2 x 0.2 cm and. 0.8 x 0.4 x 0.4 cm), entirely submitted. SECTION CODE: E1, one lymph node; E2, one lymph node, trisected. CLINICAL HISTORY. Left breast cancer. SNOMED CODES. T-04050, M-85003, M-85002 T-C4710, M-85006. "Some tests reported here may have been developed and performance characteristics. determined by. These tests have not been. specifically cleared or approved by the U.S. Food and Drug Administration.". Released by: Start of ADDENDUM #1. ADDENDUM. Addendum completed by. This report is issued to give immunohistochemistry results. Immunohistochemical staining is performed on a representative formalin-fixed, paraffin-. embedded section of INVASIVE DUCTAL CARCINOMA, left breast, block B3. MARKER. % POSITIVE. SCORE. Estrogen Receptor. Negative. 0 %. Progesterone Receptor. Negative. < 1 %. N/A. HER-2/neu. overexpression. Negative. Focal 1+. Due to the above HER-2/neu immunohistochemical staining result, gene. copy level (HER-2/neu: CEP17 signal ratio) will be evaluated by FISH. and a separate report will be issued. FOOTNOTE. Estrogen receptor was assessed by immunohistochemistry using antibody 6F11 (. Progesterone receptor was assessed by immunohistochemistry using antibody PgR1294(. HER-2/neu was assessed by immunohistochemistry using antibody AB8 (I. Released by: Start of ADDENDUM #2. ADDENDUM #2. This modified report is being issued to report the results of HER-2/neu FISH. Addendum completed by. SPECIMEN SOURCE. Left breast. SUMMARY. Tissue section of the invasive carcinoma. B3 was evaluated for HER-2/neu gene. amplification by interphase fluorescence in situ hybridization technique using the -. HER-2/neu DNA Probe Kit (LSI HER-2/neu. /CEP17. Slide adequacy is satisfactory. Sixty tumor nuclei were counted and showed an average of 1.57. copies of LSI HER-2/neu gene per nucleus and an average of 1.40 copies of CEP17 per nucleus. Negative and positive controls (established by. 1 with this batch are. appropriate. Two representative images have been archived. INTERPRETATION. The tumor cells demonstrated no amplification of the HER-2/neu gene copy levels (HER-2/neu: CEP17 signal ratio: 1.12). The following guideline has been established for HER-2/neu testing: Normal HER-2/neu levels: < 1.80; equivocal HER-2/neu levels: 1.80 - 2.20; amplified HER-2/neu. levels: > 2.20. (Ref: Arch Patholo Lab Med. 2007; 131:18-43). NOTES. The LSI HER-2/neu probe is specific for the HER-2/neu gene Locus (17q 11.2-q12) and the CEP. 17 DNA probe is specific for the alpha satellite DNA sequence at the centromeric region of. Chromosome 17 (17 p11.1-q11.2). This test has been cleared and approved for specific uses by the U.S. Food and Drug. Administration. Its system is operating within the performance specifications stated in the product. insert. Released by:

expanded version (tokens=2564) : 
 The breast pathology report indicates the following:

- Histological classification: Multifocal invasive ductal carcinoma with associated lymphocytic infiltrate, high nuclear grade, Nottingham histologic grade 3, and ductal carcinoma in situ (DCIS), high grade, predominantly cribriform and clinging types with cancerization of lobules and associated lymphocytic infiltrate.
- Subtype: Basal.
- Necrosis: No mention of necrosis.
- Tumor infiltrating lymphocytes: Associated lymphocytic infiltrate with both invasive carcinoma and DCIS.
- Histological grade: High nuclear grade, Nottingham histologic grade 3.
- Nuclear grade: High nuclear grade.
- Lymphovascular invasion: Identified.
- Calcification: No mention of calcification.
- Receptor status: Estrogen receptor-negative, progesterone receptor-negative, HER-2/neu-overexpression negative.
- Ancillary testing results: Sample was evaluated for HER-2/neu gene amplification using fluorescence in situ hybridization technique and showed no amplification of the HER-2/neu gene copy level.

Additional information from the report states that the tumor marker studies will be performed and reported in an addendum. Immunohistochemistry results show that estrogen receptor and progesterone receptor are negative, while HER-2/neu is overexpression negative. HER-2/neu gene copy level was evaluated using fluorescence in situ hybridization technique and showed no amplification of the HER-2/neu gene

prompt : Please generate a succinct report in 75 words from the above information. Exclude any filler words or sentences. If something is not mentioned or specified, exclude it from the report. Low verbosity.

final output (tokens=2729) : 
 Report: Left breast pathology shows multifocal invasive ductal carcinoma, high nuclear grade, Nottingham histologic grade 3, and basal subtype. Associated lymphocytic infiltrate is observed with both invasive carcinoma and DCIS. Lymphovascular invasion identified. Estrogen receptor-negative, progesterone receptor-negative, HER-2/neu-overexpression negative. The HER-2/neu gene was evaluated by fluorescence in situ hybridization technique and showed no amplification of the gene copy level. A metastatic carcinoma was found in one of thirty lymph nodes in the left axillary contents.

