prompt1 : extract information from  breast pathology report. List the histological classification, i.e. type of cancer or DCIS, subtype, description of any necrosis, any mention of tumor infiltrating lymphocytes,  histological grade, nuclear grade,  lymphovascular invasion, calcification, receptor status, IHC and any other ancillary testing results.  List out and expand the main points.
prompt2 : The report is - Subtype LumA, Infiltrating Lobular Carcinoma. CATEGORY: BREAST INVASIVE CARCINOMA-INFILTRATING LOBULAR. CARCINOMA. FROM PRIMARY BREAST SURGERY. CLINICAL HX - Invasive lobular carcinoma. RIGHT BREAST, MASTECTOMY - Invasive lobular carcinoma, focally pleomorphic type,. 3.0cm in greatest microscopic dimension, associated with extensive duct carcinoma in-situ. (DCIS), intermediate nuclear grade, solid type with comedo necrosis. [Nottingham histologic. grading system utilized- SBR score 7; architectural grade 3, nuclear grade 2, mitotic grade 2). No. lymphatic invasion is identified. Deep margin negative for tumor. Vessel wall calcifications. Intraductal papilloma, radial scar and fibrocystic changes including sclerosing adenosis. Skin and. nipple, unremarkable. Prior biopsy site changes. RIGHT AXILLARY CONTENTS, EXCISION - Metastatic carcinoma present in two of the. thirteen lymph nodes (2/13). Largest metastatic focus measures 4mm in greatest microscopic. dimension. No extranodal extension is identified. Comment: AJCC pathologic stage pT2N1aMx. Synoptic summary will follow as an addendum. ADDENDUM 1: RIGHT BREAST, MASTECTOMY - Immunohistochemical stain for HER-2-NEU oncoprotein. is negative (performed on formalin-fixed paraffin embedded sections by manual semiquantitative. morphometric analysis with appropriate positive and negative controls). No membranous staining. is seen. The HER-2-NEU procedure was performed using monoclonal antibody 4B5 and DAB. detection system. (Staining interpretation: Weak = 1+; Moderate = 2+; Strong = 3+.). NOTE. This evaluation was performed according to ASCO/CAP guidelines: Positive HER2/neu. cases are those with strong and complete membrane staining (3+) in greater than 30% of invasive. cancer cells. Negative cases are defined as those with no staining (0) or weak, incomplete. membrane staining (1+) in any proportion of cells. Equivocal cases are those cases with strong. staining in less than or equal to 30% of cells, or less than strong but complete membrane staining. (2+) in at least 10% of cells. Immunohistochemical stains were performed on formalin-fixed. paraffin embedded tissue with appropriate positive and negative controls. ADDENDUM 2. Specimen Type - Mastectomy. Lymph node Sampling - Axillary dissection. Specimen Size. Greatest dimension 3cm. Histologic Type - Invasive lobular. Grading System - Nottingham. Tubule Formation - Minimal less than 10% (score = 3). Nuclear Pleomorphism - Moderate. increase in size, etc (score = 2). Mitotic Count - 40X objective field with a field area of 0.152. mm2: 6 to 10 mitoses per 10 HPF (score = 2). Total Nottingham Score - Grade II: 6-7 points. Margins uninvolved by invasive carcinoma. Distance from closest margin: 5mm. Deep Primary. Tumor [pT]: pT2 - Tumor greater than or equal to 2.0-5.0cm. Regional Nodes [pN]: pN1a: Metastasis in 1 to 3 axillary lymph nodes (at least 1 tumor deposit greater than 2.0mm). Number. involved: 2. Number examined: 13. Distant Metastasis [pM]: pMX - cannot be assessed. FROM DIAGNOSIS. CLINICAL HX - Right irregular mass, Right ax tail lymph node. RIGHT BREAST, 10:00. MASS, CORE BIOPSY - Invasive, lobular carcinoma with focal duct carcinoma in situ, solid. type, low nuclear grade. Intraductal papilloma involved by lobular carcinoma in-situ. RIGHT. AXILLA, LYMPH NODE, CORE BIOPSY - Lymph node with metastatic carcinoma. histologically identical to breast carcinoma. COMMENT. Prognostic/predictive markers are. being performed and results will follow as an addendum. ADDENDUM: Results of. immunoperoxidase steroid receptor protein determination on paraffin sections, visually evaluated. using DAB detection system and monoclonal antibodies (manual semiquantitative morphometric. 7. analysis): ESTROGEN RECEPTOR PROTEIN (ER- clone SP1): POSITIVE; PROGESTERONE. RECEPTOR PROTEIN (PR- clone 1E2): POSITIVE. Estimated percentage of nuclei staining. positive (ER): 100; Estimated percentage of nuclei staining positive (PR): 25. Intensity of. staining, ER: 3+ (strong). Intensity of staining, PR: 3+ (strong). Immunohistochemical stain for. HER-2-NEU oncoprotein is NEGATIVE (performed on formalin-fixed paraffin embedded. sections by manual semiquanitative morphometric analysis). No membranous staining is seen. The HER-2-NEU procedure was performed using monoclonal antibody 4B5 and DAB detection. system. 8.

expanded version (tokens=1538) : 
 The breast pathology report reveals the following information:

1. Histological classification: Invasive Lobular Carcinoma, focally pleomorphic type, associated with extensive duct carcinoma in-situ (DCIS).

2. Subtype: LumA.

3. Description of Necrosis: There is comedo necrosis present in DCIS.

4. Tumor infiltrating lymphocytes: No tumor infiltrating lymphocytes are identified.

5. Histological grade: The Nottingham histologic grading system utilized- SBR Score 7; architectural grade 3, nuclear grade 2, mitotic grade 2.

6. Nuclear grade: Intermediate nuclear grade, solid type.

7. Lymphovascular invasion: No lymphatic invasion is identified.

8. Calcification: There is vessel wall calcification present.

9. Receptor status: ER and PR positive with an estimated percentage of nuclei staining positive for ER- 100% and PR- 25%.

10. IHC and other ancillary testing results: Immunohistochemical stain for HER-2-NEU oncoprotein is negative; performed using monoclonal antibody 4B5 and DAB detection system. No membranous staining is seen. Distance from the closest margin is 5mm. AJCC pathologic stage is pT2N1aMx. Metastatic carcinoma is present in two of the thirteen lymph nodes (2/13).

prompt : Please generate a succinct report in 75 words from the above information. Exclude any filler words or sentences. If something is not mentioned or specified, exclude it from the report. Low verbosity.

final output (tokens=1718) : 
 The breast pathology report shows invasive lobular carcinoma, pleomorphic type, with extensive DCIS and no tumor-infiltrating lymphocytes. The Nottingham histologic grading system was used, which reported a score of 7 with architectural grade 3, nuclear grade 2, and mitotic grade 2. ER/PR is positive with ER at an estimated percentage of nuclei staining at 100% and PR at 25%. Immunohistochemical staining for HER-2-NEU oncoprotein was negative. Two out of thirteen lymph nodes were positive for metastatic carcinoma. The AJCC pathologic stage is pT2N1aMx.

