prompt1 : extract information from  breast pathology report. List the histological classification, i.e. type of cancer or DCIS, subtype, description of any necrosis, any mention of tumor infiltrating lymphocytes,  histological grade, nuclear grade,  lymphovascular invasion, calcification, receptor status, IHC and any other ancillary testing results.  List out and expand the main points.
prompt2 : The report is - Subtype LumA, Final Pathologic Diagnosis: A. Right breast, biopsy: No evidence of tumor in one lymph node (0/1). B. Left axilla, sentinel lymph node #1, dissection: No evidence of tumor in three lymph. nodes (0/3). C. Right breast, mastectomy: 1. Skin with no significant pathologic abnormality. 2. Proliferative fibrocystic changes. 3. Microcalcifications in association with benign glands. D. Left breast, mastectomy: 1. Invasive carcinoma, 2.0 cm, SBR grade 2, see comment. 2. Ductal carcinoma in situ, low grade, see comment. 3. Skin with no significant pathologic abnormality. 4. Fibroadenoma. 5. Microcalcifications associated with invasive carcinoma and benign glands. 6. Proliferative fibrocystic changes. Working Draft. 7. Papillomatosis. 8. Pseudoangiomatous stromal hyperplasia. E. Nonsentinel lymph node, left axilla, dissection: No evidence of tumor in four lymph. nodes (0/4). F. Right breast, re-excision of superior portion: Benign breast parenchyma. Note: In Part D (left breast), the area indicated by the surgeon with a green stitch shows proliferative. fibrocystic changes, sclerosing adenosis, and pseudoangiomatous stromal hyperplasia. There is no. evidence of carcinoma in the area around the green suture. Breast Tumor Synoptic Comment. - Laterality: Left. - Invasive tumor type: Mixed ductal and lobular type (tumor is present in Slides D1, D2, D5, and D18). - Invasive tumor size: 2.0 cm maximum diameter (Slide D5). - Invasive tumor grade (modified Bloom-Richardson): Nuclear grade: 2 points. Mitotic count: 16 mitotic figures/10 HPF, 2 points. Tubule/papilla formation: Definite tubule formation <10%, 3 points. Total points and SBR grade = 7 points, grade 2. - Lymphatic-vascular invasion: None identified. - Perineural invasion: None identified. - Resection margins for invasive tumor: - Deep margin: Positive (Slide D2, 5). - Medial margin: Widely clear; >1 cm. - Lateral margin: Widely clear; >1 cm. - Anterior/superior margin: Widely clear; >1 cm. - Anterior/inferior margin: Widely clear; >1 cm. - Ductal carcinoma in situ (DCIS) type: Solid. - Ductal carcinoma in situ size: DCIS present as scattered microscopic foci associated with the invasive. component on Slides D1 and D2. - Ductal carcinoma in situ nuclear grade: Low grade. - Necrosis in ductal carcinoma in situ: None. - Microcalcifications: Present involving invasive carcinoma. - Resection margins for ductal carcinoma in situ: - Deep margin: Close; within less than 0.3 cm (Slide D1). - Medial margin: Widely clear; >1 cm. - Lateral margin: Widely clear; >1 cm. - Anterior/superior margin: Widely clear; >1 cm. - Anterior/inferior margin: Widely clear; >1 cm. - Lobular carcinoma in situ (LCIS): Not identified. - Lymph node status: No evidence of tumor in eight lymph nodes (0/8). - AJCC/UICC stage: pT1cNOMX. - Nontumorous breast tissue: Proliferative fibrocystic changes, Fibroadenoma, pseudoangiomatous. hyperplasia. - Nipple: Unremarkable. - Skin/dermis: Unremarkable. Immunohistochemical tests for estrogen, progesterone and Her2 Neu are pending and will follow in an. addendum. Intraoperative Consult Diagnosis. FS1 (A) Right breast nodule, biopsy: Lymph node with no tumor seen. (Dr. FS2 (B) Sentinel lymph node, left axilla, biopsy: Three lymph nodes, no tumor seen. (Dr. Working Draft. Clinical History. The patient is a. woman with breast cancer. A. tracking sheet. accompanies the specimen and indicates a high family risk for cancer and preoperative diagnosis of. known left breast cancer in the upper outer quadrant. No specimen radiograph is requested. Multifocality is suspected on the left side. Special stains for ER, PR, and HER2/neu are requested as a. repeat. The diagram indicates that the known tumor is in the upper outer quadrant of the left breast, and. a suspicious area is present in the upper inner quadrant at approximately the 11 o'clock position above. the nipple. Recent MRI indicates the presence of a known 2-cm tumor with clip present in the lateral. breast of the left breast in addition to an adjacent 5-mm lesion that is immediately posteromedial to the. primary lesion. A 5-mm suspicious area is also identified in the slightly upper inner quadrant. Gross Description. The specimen is received in six parts, each labeled with the patient's name and medical record number. Parts A through D and F are received fresh, and Part E is received in formalin. Part A is additionally labeled "right breast nodule." It consists of a single unoriented, irregular piece of. soft, pink tissue, measuring 0.7 x 0.5 x 0.3 cm. The specimen is entirely submitted for frozen section. diagnosis as FS1, with the frozen section remnant submitted in cassette A1. Part B is additionally labeled "sentinel lymph node left axilla, count - 1800, frozen section." It consists. of. a single irregular piece of soft, yellow-pink, fatty tissue, measuring 3.0 x 2.0 x 0.6 cm. The specimen is. entirely submitted for frozen section diagnosis as FS2, with the frozen section remnant submitted in. cassette B1. Part C is additionally labeled "right breast." It consists of a mastectomy specimen, oriented with a short. suture considered superior and long suture considered lateral; oriented as such, the specimen measures. 3.2 cm from anterior to posterior, 14.7 cm from medial to lateral, and 13,7 cm from superior to inferior. The mastectomy specimen weighs 212.5 gm. The specimen includes an area of skin, measuring 14.5 x. 6.7 cm, with nipple, measuring 1.7 x 1.7 x 1.5 cm, and areola, measuring 3 x 3.8 cm. The specimen has. been previously inked and serially sectioned by the. serial. slices. Inking follows standard inking, with posterior black, anterior superior blue, and anterior inferior. green. The accompanying research paperwork indicates that a fragment of tissue has been taken for. tissue banking. Cut sections reveal that the breast is composed almost entirely of homogeneous, firm,. white, fibrous tissue that abuts the deep margin. Thin layers of adipose tissue are present in the anterior. surface as well as the medial aspect of the specimen. No grossly evident lesions are identified. The nipple. and skin similarly appear unremarkable. Slice 1 is considered medial, and slice 10 is considered lateral. The nipple, thereby, is in slice 5. Representative sections are submitted as follows: Cassettes C1-C2: Nipple, entirely submitted. Cassette C3: Upper outer quadrant from slice 8. Cassette C4: Upper outer quadrant from slice 7. Cassette C5: Lower outer quadrant from slice 8. Cassette C6: Lower outer quadrant from slice 7. Cassette C7: Upper inner quadrant from slice 4. Cassette C8: Upper inner quadrant from slice 3. Cassette C9: Lower inner quadrant from slice 3. Cassette C10: Lower inner quadrant from slice 2 and section of skin from slice 4. Part D is additionally labeled "left breast," with further specification in the requisition form indicating that. a green stitch - questionable secondary cancer, correlate with MRI, and black short superior, long =. lateral. A firm, pale-tan, circumscribed lesion, measuring 1.6 x 1.2 x 1.4 cm, is present at the 3 o'clock position, 3. cm from the nipple; this contains a surgical clip. The lesion is 0.1 cm from the deep margin, 0.9 cm from. the skin, 2.2 cm from anterior superior, 1.9 cm from anterior inferior, 3.5 cm from the lateral margin, and. < 10 cm from the medial margin. Immediately inferior and medial to main lesion, a 0.4-cm area contains. multiple punctate, firm, yellow spots. This lesion is 0.5 cm from the large lesion and is 0.5 from the deep. margin. The remainder of the specimen is composed mostly of firm, fibrous tissue, showing multiple. small cystic areas, with a maximum diameter of 0.4 cm, throughout. The area adjacent to the green. suture on slice 6 similarly consists of dense, fibrous tissue, and no definitive lesions are identified in this. area. The skin, nipple, and areola appear unremarkable. Working Draft. Accompanying paperwork from the. ndicates that a portion of the. specimen has been taken for tissue banking. The specimen contains a short stitch and long black stitch,. taken to be superior and lateral, respectively, and has been previously inked and sectioned by the. research technician into ten slices, from medial to lateral. Inking is as per standard, with posterior in. black, anterior superior in blue, and anterior inferior in green. The blue ink appears faint. The. most-medial slice is taken as slice 1 and the most-lateral slice as slice 10. The specimen, thereby,. measures 2.5 cm from anterior to posterior, 15.6 cm from medial to lateral, and 16.6 cm from superior to. inferior and weighs 192.5 gm. A skin ellipse is present, measuring 6.6 x 13.1 cm, with the long axis in the. mediolateral extent. The areola measures 3.4 x 3 cm, and the nipple measures 1.8 x 1.6 x 1.6 cm. The. nipple lies in slices 5 and 6. The green nylon suture is in the posterior aspect of slice 6 at the 12 o'clock. position, 3.5 cm superior to the nipple. Representative sections are submitted as follows: Cassette D1: 1.6-cm lateral lesion in relation to deep margin from slice 8. Cassette D2: Punctate, yellow lesion from slice 8. Cassette D3: Nearest anterior-superior margin in slice 8. Cassette D4: Nearest anterior-inferior margin from slice 8. Cassette D5: Additional 1.6-cm lesion in relation to skin. Cassettes D6-D7: Nipple, entirely submitted. Cassette D8: Area marked by green suture, including skin and anterior-superior and deep. margins. Cassettes D9-D11: Additional sections of area marked by the green suture en bloc from slice 6. Cassette D12: Area adjacent to green suture from slice 5. Cassette D13: Area adjacent to green suture from slice 7. Cassette D14: Inferior margin of slice 8. Cassette D15: Superior margin of slice 8. Cassette D16: Lateral margin from slice 10. Cassette D17: Medial margin from slice 1. Cassette D18: Intervening area between primary lesion and lateral margin from slice 9. Cassette D19: Upper inner quadrant, rectangular from slice 4 and triangular from slice. 3. Cassette D20: Lower inner quadrant, rectangular from slice 5, triangular from slice 4. Cassette D21: Upper outer quadrant, rectangular from slice 8, triangular from slice 9. Cassette D22: Lower outer quadrant, triangular from slice 7, rectangular from slice 9. Part E is additionally labeled "nonsentinel lymph node left axilla." It consists of a single unoriented. fragment of largely adipose tissue, measuring 2.4 x 1.4 x 0.5 cm. A single 1.4-cm lymph node is. identified. The candidate lymph node is bisected and entirely submitted in cassette E1. The remainder of. the soft tissue is entirely submitted in cassette E2. Part F is additionally labeled "re-excision superior portion right breast" and has an additional note in the. requisition form indicating that the stitch = new margin. It consists of a single fragment of adipose. tissue, measuring 3 x 2.2 x 0.9 cm, marked by a single black suture. The surface containing the black. suture is inked in black and the opposite surface in blue. The specimen is serially sectioned to reveal. mostly adipose tissue, with a single 0.7-cm area of white, fibrous tissue. The specimen is entirely. submitted in cassettes F1 through F3. /Pathology Resident. Fee Codes: Addenda. Addendum. Date Complete: Paoe 4 of R. Working Draft. Addendum Comment. An immunohistochemical test for estrogen and progesterone receptors as well as for HER2 was performed. on block D5. The test for estrogen receptors is positive. There is strong (3+) nuclear staining in 85% of tumor cells. Internal positive control is positive. The test for progesterone receptors is. There is strong (3+) nuclear staining in~100% - of tumor cells. Internal positive control is positive. Result of HER2/neu test: This carcinoma is negative for HER2/neu oncoprotein over-expression. An immunohistochemical assay was performed using the CB11 monoclonal antibody to HER2/neu. oncoprotein. The staining intensity of this carcinoma was 1 on a scale of 0-3 (HER2 test interpreted by. Dr. Carcinomas with staining intensity scores of o or 1 are considered negative for over-expression of HER2/neu oncoprotein. Those with a staining intensity score of 2 are considered borderline. We and others have observed that many carcinomas with staining. intensity scores of 2 do not show gene amplification. All carcinomas with staining intensity scores of 2 are therefore submitted for. FISH testing. The results of the FISH test are issued directly from the molecular cytogenetics laboratory. Carcinomas with staining intensity scores of 3 are considered positive for over-expression of HER2/neu oncoprotein. Tumors in this. category show an excellent correlation between the results of immunohistochemical and FISH testing, and almost always show gene. amplification. The immunoperoxidase stain(s) reported above were developed and their performance characteristics determined by the. They have not been cleared or approved by the U. S. Food and Drug Administration. Tne FDA has. determined that such clearance or approval is not necessary. These tests are used for clinical purposes. They should not be regarded. as investigational or for research. This laboratory is certified under the Clinical Laboratory Improvement Amendments of 1988 ("CLIA"). as qualified to perform high-complexity clinical testing. /Pathologist. Addendum. Date Complete: Addendum Comment. An immunohistochemical test for progesterone receptors was performed on block D5. The test for progesterone receptors is positive. There is strong nuclear staining in - -100% of tumor cells. The immunoperoxidase stain(s) reported above were developed and their performance characteristics determined by the. They have not been cleared or approved by the U. S. Food and Drug Administration. The FDA nas. determined that such clearance or approval is not necessary. These tests are used for clinical purposes. They should not be regarded. as investigational or for research. This laboratory is certified under the Clinical Laboratory Improvement Amendments of 1988 ("CLIA"). as qualified to perform high-complexity clinical testing. (Pathologist. Working Draft. Other Specimens. Specimen Class: Accessioned: Specimen(s) Received: Rectal, polyp. Final Diagnosis. Rectum, polypectomy: Hyperplastic polyp. Specimen Class: Accessioned: Specimen(s) Received: Pelvic Washing. Final Diagnosis. Pelvic Washing. BENIGN. Reactive mesothelial cells. Specimen Class: Accessioned: Specimen(s) Received: A: Risk reducing salpingo-oophorectormy- right ovary- FS, B: Risk reducing salpingo-oophorectormy-. left ovary- FS, C: Endometrium, curettage- perm, D: Endocervix, curettage- perm. Final Diagnosis. A. Right ovary, salpingo-oophorectomy: No significant pathologic abnormality; see. comment. B. Left ovary, salpingo-oophorectomy: No significant pathologic abnormality; see. comment. C. Endometrium, curettage: Tissue insufficient for accurate evaluation; see. comment. D. Endocervix, curettage: Scant fragments of squamous and glandular epithelium. with no significant pathologic abnormality. Specimen Class: Accessioned: Specimen(s) Received: Cervical, Thin Prep Imaged. Final Diagnosis. Cervical, Thin Prep Imaged. NEGATIVE FOR INTRAEPITHELIAL LESION OR MALIGNANCY. Atrophic pattern. Inflammation. Working Draft. SPECIMEN ADEQUACY: Satisfactory for evaluation; atrophic pattern with no identifiable. endocervical/transformation zone component. Specimen Class: Accessioned: Specimen(s) Received: Cervical/Endocervical, Thin Prep Imaged. Final Diagnosis. Cervical/Endocervical, Thin Prep Imaged. NEGATIVE FOR INTRAEPITHELIAL LESION OR MALIGNANCY. Atrophic changes. SPECIMEN ADEQUACY: Satisfactory for evaluation; atrophic pattern with no identifiable. endocervical/transformation zone component. Specimen Class: Accessioned. Specimen(s) Received: Left breast core needle biopsy at 2:30, N + 3-4. Final Diagnosis. Left breast, needle core biopsy: Invasive carcinoma; see comment. MD. Procedure/Addenda for. ADDENDUM. Date of Addendum.: Addendum Comment. Immunohistochemical stain for E-Cadherin was performed and evaluated on A1. The invasive carcinoma. shows area with moderate membrane staining and others that are negative or demonstrate granular. staining. Thus, this invasive carcinoma displays features of both ductal and lobular carcinoma. Dr. has reviewed the immunohistochemical stained slide and concurs. The immunoperoxidase stain(s) reported above were developed and their performance characteristics. determined by the. They have not been cleared or. approved by the U. S. Food and Drug Administration. The FDA has determined that such clearance or. approval is not necessary. These tests are used for clinical purposes. They should not be regarded as. investigational or for research. This laboratory is certified under the Clinical Laboratory Improvement. Amendments of 1988 ("CLIA") as qualified to perform high-complexity clinical testing. Specimen Class: Accessioned: Specimen(s) Received: Left Axilla Lymph Node, Fine Needle Aspiration. Working Draft. Final Diagnosis. Left Axilla Lymph Node, Fine Needle Aspiration: Benign reactive lymph node, see note. This lymph node shows a spectrum of small to large sized lymphocytes with scattered. tingible body macrophages. No evidence of neoplasia is seen. Specimen Class: Accessioned: Specimen(s) Received: Left Breast, Fine Needle Aspiration. Final Diagnosis. Left Breast, Fine Needle Aspiration: Adenocarcinoma, see comment. Procedure/Addenda for. ADDENDUM. Date of Addendum.: Acdendum Comment. An immunohistochemical test for estrogen and progesterone receptors as well as for HEr-2-neu was. performed on the material submitted for cell block. The test for estrogen receptors is positive There is strong nuclear staining in 90% of tumor cells. The test for progesterone receptors is positive. There is strong nuclear staining in 80% of tumor cells. Result of HER2/neu test: This carcinoma is borderline for HER2/neu oncoprotein over-expression. An immunohistochemical assay was performed on cell block using the CB11 monoclonal antibody to. HER2/neu oncoprotein. The staining intensity of this carcinoma was 2 on a scale of 0-3. Carcinomas with staining intensity scores of o or 1 are considered negative for over-expression of. HER2/neu oncoprotein. Those with a staining intensity score of 2 are considered borderline. We and others have observed that. many carcinomas with staining intensity scores of 2 do not show gene amplification. All carcínomas with. staining intensity scores of 2 are therefore submitted for FISH testing. The results of the FISH test are. issued directly from the molecular cytogenetics laboratory. Carcinomas with staining intensity scores of 3 are considered positive for over-expression of HER2/neu. oncoprotein. Tumors in this category show an excellent correlation between the results of. immunohistochemical and FISH testing, and almost always show gene amplification. Dr. has reviewed the HER2/neu stain and concurs.

expanded version (tokens=5070) : 
 Histological Classification:
- Right breast, biopsy: No evidence of tumor
- Left axilla, sentinel lymph node #1, dissection: No evidence of tumor
- Right breast, mastectomy: Invasive carcinoma, 2.0 cm, SBR grade 2, Ductal carcinoma in situ, low grade
- Left breast, mastectomy: Invasive carcinoma, 2.0 cm, SBR grade 2, Ductal carcinoma in situ, low grade

Description of Necrosis: None mentioned in the report

Tumor Infiltrating Lymphocytes: Not mentioned in the report

Histological Grade: SBR grade 2 (for invasive carcinoma)

Nuclear Grade: Low grade (for ductal carcinoma in situ)

Lymphovascular Invasion: None identified

Calcification: Microcalcifications present involving invasive carcinoma

Receptor Status:
- Estrogen Receptor: Positive in 85% of tumor cells
- Progesterone Receptor: Positive in 100% of tumor cells
- HER2/neu: Negative for over-expression

IHC and Ancillary Testing Results:
- E-Cadherin: Moderate membrane staining in some areas, negative or granular staining in others
- FISH test for HER2/neu: Borderline result, further testing may be required

Main Points:
- The patient underwent mastectomy for invasive ductal carcinoma in the left breast, which measures 2.0 cm and is S

prompt : Please generate a succinct report in 75 words from the above information. Exclude any filler words or sentences. If something is not mentioned or specified, exclude it from the report. Low verbosity.

final output (tokens=5197) : 
 Left breast: 2.0 cm invasive carcinoma (SBR grade 2) with low-grade ductal carcinoma in situ. No necrosis or lymphovascular invasion detected. Estrogen receptor positive in 85% of tumor cells, progesterone receptor positive in 100% of tumor cells. HER2/neu negative for over-expression. Further testing required for HER2/neu status confirmation.

