prompt1 : extract information from  breast pathology report. List the histological classification, i.e. type of cancer or DCIS, subtype, description of any necrosis, any mention of tumor infiltrating lymphocytes,  histological grade, nuclear grade,  lymphovascular invasion, calcification, receptor status, IHC and any other ancillary testing results.  List out and expand the main points.
prompt2 : The report is - Subtype LumA, Path No.: Client: (Age: )F. Soc. Sec. #: Pre-Operative/Clinical History. Left breast cancer. Specimen(s) Received. A: LEFT AXILLA SENTINEL LYMPH NODE #1. B: LEFT AXILLA SENTINEL LYMPH NODE #2. C: LEFT AXILLA, ADDITIONAL AXILLARY TISSUE. D: BREAST, MASTECTOMY. Gross Description. Specimen A, received in formalin labeled left axilla sentinel node #1, consists of adipose tissue, 3.5 x 1.5 x 1.3 cm. Sections show a lymph node measuring 2.0 cm in greatest dimension, partially replaced by adipose tissue. The node is. sectioned and entirely submitted labeled (A1, A2). Specimen B, received in formalin labeled left axilla sentinel node #2, consists of adipose tissue, 2.0 x 1.5 x 0.8 cm. Sections show a single lymph node candidate measuring 1.0 cm in greatest dimension. The node is sectioned and. entirely submitted. (B1). Specimen C, received In formalin labeled left axilla additional axiliary tissue, consists of adipose tissue, 4.0 x 2.5 x 2.0 cm. in aggregate. Sections show a single lymph node candidate, 0.3 cm in greatest dimension. (C1). Microscopic Description. The microscopic findings are reflected in the diagnosis rendered. Diagnosis. A). LYMPH NODE, LEFT AXILLARY SENTINEL #1, EXCISION: ONE LYMPH NODE INVOLVED BY METASTATIC MAMMARY CARCINOMA (9 MM, NEGATIVE FOR. EXTRACAPSULAR EXTENSION). B). LYMPH NODE, LEFT AXILLARY SENTINEL #2, EXCISION: ONE LYMPH NODE INVOLVED BY MICROMETASTATIC MAMMARY CARCINOMA (1 MM, NEGATIVE. FOR EXTRACAPSULAR EXTENSION). C). LYMPH NODE; LEFT AXILLARY NONSENTINEL, EXCISION: ONE LYMPH NODE NEGATIVE FOR TUMOR. PHD HISTOLOGY REPORT. électronically Reviewed and Signed Out By. Comment. All sentinel node blocks were examined with three 80 um interval H&E stained continu and two 80 um interval cytokeratin. AE1/AE3 immunostains. Positive and negative controls react satisfactorily. FDA required disclaimer: These tests were developed and their performance characteristics determined by. They have not been cleared. or approved by the U.S: Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. These tests are used. for clinical purposes and should not be regarded as investigational or for research. This laboratory is certified under the Clinical Improvement. Amendments of 1988 (CLIA) as qualified to perform high complexity clinical laboratory testing. aquired information for predictive/prognostic markers: 1. Type of specimen fixation and detection system: Tissue is fixed in 10% formalin. Indirect biotin-free detection kit is used. 2. Clones used: ER (clone 6F11) Novocastra; PR (clone PGR 636). DakoCytomation; CD117 (polycional, DakoCytomation); HER2 (clone 485, Ventana, FDA approved); Ki-67 (clone K3, Cell Marque) p53 (cione DO7,. Novocastra), MSH6 (clone BC-44, Biocare), MSH2 (CellMarque clone G219-1129), MLH1 (Cell Marque clone G168-728), PMS2 (clone MRQ-28, Cell. Marque). 3. Criteria for positive results: ER and PR: >1% of tumor cells with nuclear staining; HER2; >30% of cells show complete membrane staining;. p53: >10% of tumor cells with nuclear staining; MMR Proteins: complete absence of tumor nuclear staining. CPT Code(s). A: 88307, 88342,. B: 88307, 88342,. C: 88305. D: 88307, 3260F. Procedures/Addenda. ADDENDUM. Addendum Comment. Gross Description. Specimen D is received in formalin labeled left breast, suture = axillary tail. Specimen type: Mastectomy without axillary tail and without pectoralis muscle. The specimen is oriented. by the surgeon as follows: suture = axillary tail. Specimen size/description: 755 gm. SI 17.5 cm, ML 16.5 cm, AP 6.0 cm. Laterality: Left. Tumor size: 3.0 x 2.5x 2.0 cm. Tumor site: Upper inner quadrant, 10-11 o'clock. Tumor description: Stellate, gritty, tan-white with a central 1.0 x 1.0 x 0.7 cm hemorrhagic ill-defined biopsy. site. Deep margin: 1.5 cm. Nipple/areolar complex: The areola measures 3.5 cm with a centrally retracted 0.6 x 0.6 cm nipple. There is a 5.5. x 4.0 cm area of blue dye superior the nipple/areolar area. PHD HISTOLOGY REPORT. Skin: The ellipse measures 22.0 x 10.5 cm. Lymph node sampling: Not applicable. Other: Sectioning of the surrounding breast tissue shows predominantly yellow lobular adipose. tissue admixed with dense, granular cystic breast tissue. Sections are submitted as follows: (D1,2) Nipple. (D3-7) Mass. (D8, 9) Upper inner quadrant. (D10, 11). Lower inner quadrant. (D12, 13). Lower outer quadrant. (D14, 15). Upper outer quadrant. (D16, 17). Deep margin. EO:vyb. ADDENDUM. Addendum Diagnosis. D) BREAST, LEFT, TOTAL MASTECTOMY: INVASIVE LOBULAR CARCINOMA, 3.0 CM, LOW COMBINED HISTOLOGIC GRADE WITH LOW. PROLIFERATIVE RATE. SURGICAL MARGINS NEGATIVE FOR TUMOR (SEE COMMENT). Addendum Comment. Summary of Pathologic Findings. Breast Carcinoma. Microscopic Examination. Specimen: Total breast. Procedure: Total mastectomy. Lymph node sampling: Sentinel node biopsies. Specimen Integrity: Single intact specimen. Specimen size: 17.5 cm greatest dimension. Laterality: Left. Tumor site: Upper inner quadrant, 9-10 o'clock position per previous diagnostic core biopsy. Size of invasive component: 3.0 cm greatest dimension. Tumor focality: Single focus. PHD HISTOLOGY REPORT. Macroscopic and microscopic extent of tumor: Skin: Uninvolved. Nipple: Paget disease absent. Skeletal muscle: Not present. Histologic type: Invasive lobular carcinoma. Combined histologic grade: Low combined histologic grade with low proliferative rate. Tubule formation: 3. Nuclear pleomorphism: 1. Mitotic count: 1 (field area 0.23 mm2). Total Nottingham score: 5. Lymph-vascular invasion: Absent. Ductal carcinoma in situ: Absent. Extensive intraductal component (EIC): Not applicable. Extent: Not applicable. Lobular carcinoma in situ: Absent. There are focal areas of atypical lobular hyperplasia. Deep margin: Not involved. Lymph nodes: Number of sentinel nodes examined: 2. Total number of nodes examined: 3. Number of nodes with macrometastasis: 1. Number of nodes with micrometastasis: 1. Number of nodes with isolated tumor cells: 0. Size of largest metastatic deposit: 9 mm. Extracapsular extension: Negative. Method of evaluation of sentinei lymph nodes: Three 80 um interval H&E stained sections and two 80 um interval cytokeratin AE1/AE3 immunohistochemical. stains on all sentinel lymph node blocks. TNM stage: pT2 N1a. Anciliary studies (estrogen receptor. progesterone receptor, HER2/neu and Ki-67): Performed on previous specimen,. see report for results. ADDENDUM. PHD HISTOLOGY REPORT. Addendum Comment. Total fixation time in formalin: 31.0 hours.

expanded version (tokens=2263) : 
 Here is the information extracted from the pathology report:

- Histological classification: Invasive lobular carcinoma
- Subtype: LumA
- Necrosis: There is a central 1.0 x 1.0 x 0.7 cm hemorrhagic ill-defined biopsy site
- Tumor infiltrating lymphocytes: Not mentioned
- Histological grade: Low combined histologic grade with low proliferative rate
- Nuclear grade: 1
- Lymphovascular invasion: Absent
- Calcification: Not mentioned
- Receptor status: ER and PR positive (>1% of tumor cells with nuclear staining), HER2 negative (>30% of cells show complete membrane staining)
- IHC results: CD117, Ki-67, p53, MSH6, MSH2, MLH1, PMS2, all negative for tumor
- Ancillary testing results: The report mentions previous testing for estrogen receptor, progesterone receptor, HER2/neu, and Ki-67, but does not provide results

Overall diagnosis: Left breast cancer with metastasis to one lymph node in the left axillary sentinel #1 (9mm), and one micrometastasis in the left axillary sentinel #2 (1mm). The surgical margins are negative for tumor. Tumor size is 3.0 x 2.5x 2.0 cm, located in the upper inner quadrant, and classified as LumA subtype invasive lob

prompt : Please generate a succinct report in 75 words from the above information. Exclude any filler words or sentences. If something is not mentioned or specified, exclude it from the report. Low verbosity.

final output (tokens=2420) : 
 The left breast tumor is LumA subtype invasive lobular carcinoma, with a low combined histological grade and low proliferative rate. It is ER and PR positive, HER2 negative, and lacks tumor infiltrating lymphocytes or lymphovascular invasion. The tumor is 3.0 x 2.5 x 2.0 cm in size, with metastasis to one axillary sentinel lymph node (9mm) and one micrometastasis in another sentinel. Surgical margins are negative for tumor, with no calcification observed.

