prompt1 : extract information from  breast pathology report. List the histological classification, i.e. type of cancer or DCIS, subtype, description of any necrosis, any mention of tumor infiltrating lymphocytes,  histological grade, nuclear grade,  lymphovascular invasion, calcification, receptor status, IHC and any other ancillary testing results.  List out and expand the main points.
prompt2 : The report is - Subtype LumA, Diagnosis: A: Breast, left, total mastectomy. Tumor type: invasive lobular carcinoma. Nottingham combined histologic grade: 2. Tubule formation score: 3. Nuclear pleomorphism score: 2. Mitotic count score: 1. Focality of tumor: single focus. Tumor site: upper outer and lower outer quadrants. Tumor size (greatest dimension) : 4.1 cm (see comment). Lymphovascular invasion: none identified. Ductal carcinoma in situ (DCIS) : none identified. Lobular carcinoma in situ (LCIS) : present. Nipple involvement : not involved. Skin involvement : not involved. Skeletal muscle involvement: not applicable. Margin status: Invasive component : Margins free of carcinoma, closest is black. inked posterior margin at 2 mm. Size of largest metastasis : 4.1 cm. Extracapsular extension: absent. Axillary lymph nodes (from parts B-G) : Total number with metastasis : 2. Total number examined: 7. Size of largest metastatic focus: 0.7 cm. Extracapsular extension: absent. Microcalcifications: associated with benign breast changes. Other pathologic findings: Extensive stromal fibrosis with patchy amyloid deposition. - Fibrocystic changes. - Columnar cell change. - Epidermal inclusion cyst. - Previous biopsy site changes. AJCC PATHOLOGIC TNM STAGE: pT2 pN1a. BREAST STAGE GROUPING: IIB. Note: This pathologic stage assessment is based on information. available at the time of this report, and is subject to change. pending clinical review and additional information. Ancillary studies previously performed on core biopsy case and. reported as : Estrogen receptor: positive, 88%, 3+. Progesterone receptor: positive, 82%, 3+. HER2/neu: negative for overexpression, 0. B: Lymph node, left axillary sentinel lymph node #1, biopsy. - One lymph node positive for metastatic carcinoma (1/1) based. on H & E and cytokeratin stained slides. - Metastatic focus measures 0.5 cm. - No extracapsular extension is identified. - Amyloid present. C: Lymph node, left axillary sentinel lymph node #2, biopsy. - One lymph node negative for metastatic carcinoma (0/1) based. on H & E and cytokeratin stained slides. - Amyloid present. D: Lymph node, left axillary sentinel lymph node #3, biopsy. - One lymph node positive for metastatic carcinoma (1/1) based. on H & E and cytokeratin stained slides. - Metastatic focus measures 0.7 cm. - No extracapsular extension is identified. - Amyloid present. E: Lymph node, left axillary sentinel lymph node #4, biopsy. - Two lymph nodes negative for metastatic carcinoma (0/2) based. on H & E and cytokeratin stained slides. - Amyloid present. F: Lymph node, left axillary sentinel lymph node #5, biopsy. - One lymph node negative for metastatic carcinoma (0/1) based. on H & E and cytokeratin stained slides. - Amyloid present. G: Lymph node, left axillary sentinel lymph node #6, biopsy. - One lymph node negative for metastatic carcinoma (0/1) based. on H & E and cytokeratin stained slides. - Amyloid present. Clinical History: -year-old female with left breast invasive lobular carcinoma. Gross Description: Received are seven appropriately labeled containers. Container A: Specimen fixation: formalin. Time in fixative: 33 hours. Cold ischemic time: 71 mins. Type of mastectomy: left total mastectomy. Weight of specimen: 330 grams. Size of specimen: anterior to posterior, 2.5 cm; superior to. inferior, 19.0 cm; medial to lateral, 20.0 cm. Orientation of specimen: The specimen is oriented with a stitch. in the axillary tail. Inking: anterior=blue, posterior=black, axillary tail=dotted. yellow. Skin ellipse dimensions: 19.0 X 5.8 cm. Nipple/areola 1.4 cm/3.0 cm. Axillary tail: present, minimal tissue. Biopsy site: absent. Discrete Mass (es) : Area of fibrotic, homogeneously firm,. white/tar tissue. Number of discrete masses : one. Size of fibrotic tissue: 7.5 cm from medial to lateral, 6.7 cm. from superior to inferior, and 3.5 cm from anterior to posterior. Location of fibrotic tissue: upper inner quadrant, upper outer. quadrant, lower outer quadrant (includes the area deep to the. nipple/areola). Distance of mass/biopsy site from surgical margin: The fibrotic. tissue abuts the black inked deep margin extensively, it also. abuts the blue inked anterior margin in multiple slices. Gross involvement of skin or fascia/muscle by tumor: The tumor. extends very close to the skin, however, does not appear to. grossly involve the skin. Description of remaining breast : predominantly yellow lobular. adipose tissue. Other remarkable features : none. Tissue submitted for special investigations: Tumor and normal. submitted to Tissue Procurement foundation. Block Summary: A1 - nipple, perpendicular sections, in relation to the tumor. A2 - nipple, perpendicular sections, in relation to the tumor. A3, A4 - perpendicular sections of the areola, in relationship to. the deep tumor. A5, A6 - representative section of the tumor, in relation to the. blue inked inferior margin. A7, A8 - representative section of the tumor, in relation to the. black inked deep margin. A9,A10 - additional representative sections of the mass. A11 - representative section, upper outer quadrant. A12 - representative section, lower outer quadrant. A13 - representative section, upper inner quadrant. A14 - representative section, lower inner quadrant. Additional sections, upper outer quadrant surrounding metallic. clip, lateral to medial: A19 - one section bisected. A20 - one section bisected. A21-A22 - - one section bisected. A23-A24 - one section bisected. A25 - one section. A26 - one section. A27 - one section. A15-A18, A28-A67 additional sections from lateral towards. medial, respectively. Container B is additionally labeled "lymph node, left axillary. sentinel lymph node #1. Received is a single, unoriented,. yellow lobular adipose tissue fragment, 3.7 X 3.0 X 1.0 cm. A. single lymph node candidate, 2.2 X 1.3 X 0.8 cm is identified. and is sequentially sectioned at 2 mm intervals. The entire. lymph node is submitted in blocks B1 and B2. Adipose tissue. remains in the container. Container C is additionally labeled "lymph node, left axillary. sentinel lymph node #2. Received is a single, unoriented,. brown/tan fibroadipose tissue fragment, 3.4 X 2.3 X 1.3 cm. A. single, possibly two, lymph node candidates matted together are. identified, 2.3 X 2.3 X 0.8 cm. The lymph node candidate is. serially sectioned at approximately 2 mm intervals and is. entirely submitted in blocks C1-C3. Adipose tissue remains in. the container. Container D is additionally labeled "lymph node, left axillary. sentinel lymph node #3. " Received is a single, unoriented,. brown/tan fibroadipose tissue fragment, 1.8 X 1.8 X 1.5 cm. A. single lymph node candidate, 1.2 X 0.8 X 0.8 cm is identified,. is serially sectioned at approximately 2 mm intervals and. entirely submitted in blocks D1 and D2. Adipose tissue remains. in the container. Container E is additionally labeled "lymph node, left axillary. sentinel lymph node #4. " Received is a brown/tan, single,. unoriented fibroadipose tissue fragment, 1.5 X 1.0 X 0.9 cm. Two. lymph node candidates, 0.5 and 0.2 cm in diameter are. identified. The larger lymph node is bisected and submitted in. block E1. The smaller lymph node is submitted in block E2. without sectioning. Adipose tissue remains in the container. Container F is additionally labeled "lymph node, left axillary. lymph node #5. " Received is a single, unoriented, brown/tan. fibroadipose tissue fragment, 1.2 X 1.2 X 0.6 cm. A single lymph. node candidate, 1.1 X 0.8 X 0.6 cm is identified. The lymph node candidate is serially sectioned at approximately. 2 mm intervals and entirely submitted in block F1. Adipose. tissue remains in the container. Container G is additionally labeled "lymph node, left axillary. sentinel lymph node #6. Received is a single, gray/tan,. unoriented, 1.0 X 0.9 x 0.6 cm lymph node candidate. The. specimen is serially sectioned, at approximately 2 mm. intervals, and entirely submitted in blocks G1 and G2,.

expanded version (tokens=2471) : 
 Histological classification: invasive lobular carcinoma 

Subtype: LumA 

Necrosis: none identified 

Tumor infiltrating lymphocytes: not mentioned

Histological grade: Nottingham combined histologic grade 2 

Nuclear grade: score of 2 for nuclear pleomorphism 

Lymphovascular invasion: none identified 

Calcification: present, associated with benign breast changes 

Receptor status: 

- Estrogen receptor: positive, 88%, 3+ 
- Progesterone receptor: positive, 82%, 3+ 
- HER2/neu: negative for overexpression 

Ancillary testing: previously performed and reported in the report 

AJCC PATHOLOGIC TNM STAGE: pT2 pN1a 

Breast stage grouping: IIB 

Main points: The diagnosis is invasive lobular carcinoma with a LumA subtype. No necrosis or tumor infiltrating lymphocytes were identified. The histological and nuclear grades indicate moderate differentiation. Lymphovascular invasion was not identified but one or more lymph nodes had metastatic carcinoma. There were no gross skin or fascia/muscle involvement by the tumor, but it extended close to the skin. Receptor status for estrogen and progesterone was positive, and HER2/neu was negative. Calcification was present but associated with benign breast changes. The AJCC PATHOLOGIC TNM STAGE is pT2 pN1a, and the breast stage grouping

prompt : Please generate a succinct report in 75 words from the above information. Exclude any filler words or sentences. If something is not mentioned or specified, exclude it from the report. Low verbosity.

final output (tokens=2613) : 
 Left total mastectomy showed invasive lobular carcinoma with LumA subtype. The tumor was not necrotic and had no reported lymphovascular invasion but was moderately differentiated with one or more positive lymph nodes. Receptor status for estrogen and progesterone was positive, and HER2/neu negative. Calcification, associated with benign breast changes was present. Pathological TNM stage is pT2 pN1a. AJCC breast stage grouping is IIB.

