prompt1 : extract information from  breast pathology report. List the histological classification, i.e. type of cancer or DCIS, subtype, description of any necrosis, any mention of tumor infiltrating lymphocytes,  histological grade, nuclear grade,  lymphovascular invasion, calcification, receptor status, IHC and any other ancillary testing results.  List out and expand the main points.
prompt2 : The report is - Subtype Basal, Patient:4. Surgical Pathology: Additional Info. CLINICAL HISTORY: Left breast carcinoma. GROSS EXAMINATION: A. "Left breast tissue 3.5 x 2 x 2 AF1", received fresh. A previously. incised unoriented 5.4 x 4.8 x 3.5 cm portion of yellow-white fibrofatty. tissue. There is a 3.5 x 2 x 2 cm firm variegated yellow-gray sabulous mass. focally abutting the margin. Representative tissue from the mass is frozen as. AF1, the remnant is submitted as A1. The majority of the remainder of the. mass is submitted as A2-A5. B. "Left breast", received fresh. A 10360 gram 33 x 21 x 5. 5 cm mastectomy. composed of a 29 x 16.3 cm ellipse of tan brown skin with underlying 28 x 21. x. 5.5 cm of fibrofatty breast tissue and contiguous 9.0 x 5.8 x 2.4 cm of. axillary contents. There is a central 5.5 cm areolar with a central everted. 1.3 cm nipple. 6 cm lateral to the edge of the areolar is an 8 cm freshly. sutured incision. The surgical margin is marked with blue ink and the. specimen is sectioned to reveal an approximately 6 cm diameter cavity 0.6 cm. subjacent to the previously described skin incision. The cavity is within 1.4. cm of the deep margin and 3 cm from the closest soft tissue margin. (inferior) The biopsy cavity is in the outer half of the specimen and has. slightly indurated borders but no residual tumor grossly appreciated. The. remainder of the breast parenchyma is composed primarily of yellow adipose. tissue intermixed with focal dense pink fibroconnective tissue and no. additional lesions noted. Block Summary: B1 - Nipple. B2 - Edge of incision and underlying cavity. B3 - Cavity in relationship to deep margin. B4 - Representative of closest soft tissue margin (inferior) . B5- Representative random cavity wall. B7 - Random lower outer quadrant. B8 Random upper outer quadrant. B9 - Representative central parenchyma. B10 - Lower inner quadrant. B11 - Upper inner quadrant. B12 - One lymph node candidate, proximal. B13 - Four lymph node candidates, mid. B14 - One bisected lymph node candidate, mid. B15-17 Largest section of lymph node candidate, mid (4.7 x 2.4 x 0.9 cm. B18 - Two lymph node candidates, distal. INTRA OPERATIVE CONSULTATION: A. "Left breast tissue": AF1 - invasive carcinoma present. DIAGNOSIS: A. "LEFT BREAST TISSUE" (EXCISIONAL BIOPSY) : INFILTRATING CARCINOMA PRESENT, HISTOLOGIC TYPE. DUCTAL. N.S.A.B.P. NUCLEAR GRADE 3 OF 3. N.S.A.B.P HISTOLOGIC GRADE 3 OF 3. GROSS TUMOR SIZE: 3.5 x 2 x 2 CM. SIZE OF INVASIVE COMPONENT: 3.5 X 2 x 2 CM. LYMPHATIC/VASCULAR INVASION: ABSENT. MULTIFOCAL TUMOR: ABSENT. 1 of 2. IN-SITU CARCINOMA: PRESENT, OCCUPYING 50% OF TUMOR (SEE COMMENT). TYPE OF IN-SITU CARCINOMA: COMEDO, MICROPAPILLARY. SIZE OF IN-SITU CARCINOMA: APPROXIMATELY SIZE OF BIOPSY (5.4 CM) . EXTENSIVE INTRADUCTAL COMPONENT: PRESENT. STATUS OF NON-NEOPLASTIC BREAST TISSUE: NOT APPLICABLE. SIZE OF BIOPSY: 5.4 x 4.8 x 3.5 CM. MICROCALCIFICATIONS: FOCALLY PRESENT. SURGICAL MARGIN STATUS: NOT EVALUATED. ESTROGEN/PROGESTERONE RECEPTOR AND CELL CYCLE ANALYSIS: PENDING. METHODOLOGY: IMMUNOHISTOCHEMISTRY, PARAFFIN BLOCK A4. RESULTS WILL BE ISSUED IN AN ADDENDUM. COMMENT: The tumor mass is a complex admixture of invasive and in-situ. carcinoma. The exact percentage of invasive carcinoma is difficult to. determine with certainty, but is estimated at approximately 50%. B. "LEFT BREAST (MODIFIED RADICAL MASTECTOMY) : RESIDUAL INFILTRATING CARCINOMA ABSENT. RESIDUAL IN SITU CARCINOMA PRESENT. TYPE OF IN-SITU CARCINOMA MICROPAPILLARY. SIZE OF IN-SITU CARCINOMA: SEE COMMENT, EXTENSIVE. NIPPLE STATUS, FREE OF TUMOR. SKIN STATUS, FREE OF TUMOR. MUSCLE STATUS, NOT SAMPLED. STATUS OF NON-NEOPLASTIC BREAST TISSUE: FIBROCYSTIC CHANGES. SURGICAL MARGIN STATUS: NEGATIVE. LYMPH NODE STATUS: SEVEN LYMPH NODES, NO EVIDENCE OF MALIGNANCY (0/7). COMMENT: Random sections around the biopsy site show foci of residual in-situ. carcinoma. In addition, a random section in the central breast several cm. away from the biopsy site is also positive for in-situ carcinoma, indicating a. rather large area involved by residual in-situ disease. The margins of. resection are negative, however. I certify that I personally conducted the diagnostic evaluation of the above. specimen (s) and have rendered the above diagnosis (es). ADDENDUM 1: Tissue was sent to the image cytometry laboratory for assay of the estrogen. and progesterone receptors. The estrogen receptor activity was judged to be. negative with an estimated FMOL value of 0. The progesterone receptor activity. was judged as negative with an estimated FMOL value of 0. Please refer to. For a complete report. I certify that I personally conducted the diagnostic evaluation of the above. specimen (s) and have rendered the above diagnosis (es). 2 of 2.

expanded version (tokens=1725) : 
 Histological classification: Infiltrating carcinoma, ductal type, with a histological grade of 3 out of 3. In-situ carcinoma, comedo and micropapillary type, occupying 50% of the tumor.

Subtype: Basal

Necrosis: No mention of necrosis.

Tumor infiltrating lymphocytes: No mention of tumor infiltrating lymphocytes.

Histological grade: Histological grade of 3 out of 3.

Nuclear grade: Nuclear grade of 3 out of 3.

Lymphovascular invasion: Absent.

Calcification: Focally present.

Receptor status: Estrogen and progesterone receptor negative.

IHC and ancillary testing results: Estrogen and progesterone receptor activity was negative. No other ancillary testing results were mentioned.

Other information: Multifocal tumor was absent, while the in-situ component occupied 50% of the tumor and was extensive. The surgical margin status was not evaluated in the biopsy tissue, but in the mastectomy tissue it was negative. Seven lymph nodes were removed and showed no evidence of malignancy.

prompt : Please generate a succinct report in 75 words from the above information. Exclude any filler words or sentences. If something is not mentioned or specified, exclude it from the report. Low verbosity.

final output (tokens=1859) : 
 Infiltrating basal carcinoma with ductal histology grade 3. In-situ carcinoma, comedo and micropapillary type, occupying 50% of tumor with extensive intraductal component. Necrosis and lymphovascular invasion absent. Multifocal tumor not present but calcifications focally present. Hormone receptor status negative. Surgical margin status negative in mastectomy tissue and lymph nodes showed no malignancy.

