prompt1 : extract information from  breast pathology report. List the histological classification, i.e. type of cancer or DCIS, subtype, description of any necrosis, any mention of tumor infiltrating lymphocytes,  histological grade, nuclear grade,  lymphovascular invasion, calcification, receptor status, IHC and any other ancillary testing results.  List out and expand the main points.
prompt2 : The report is - Subtype Basal, Patien. Surgical Pathology: Additional Info. CLINICAL HISTORY: Right breast carcinoma. GROSS EXAMINATION: A. "Righty breast tissue (AF1) ", received fresh. An oriented breast excision. with sutures as follows: Long - lateral, short - superior, (Dr. 1. A. 4.3 x 0.8 cm ellipse of tan skin with a 6.8 x 5.2 x 3.4 cm of underlying. fibrofatty breast tissue is inked as follows: Superior - blue, inferior -. black, posterior - green. The specimen is sectioned from lateral to medial to. reveal a circumscribed firm yellow sabulous 2.4 x 1.5 x approximately 1.5 cm. mass. The mass is within 0.1 cm of the green inked posterior margin and. within 0.2 cm of the blue inked superior margin. The lesion's edge is. approximately 0.4 cm from the black inked inferior margin, 2.5 cm subjacent to. the skin surface and approximately 0.6 cm from the lateral margin. The. adjacent parenchyma is composed of lobules of yellow-pink adipose intermixed. with focally dense white-pink fibroconnective tissue with no additional. lesions noted. Representative sections from the mass is frozen as AF1. The. remnant is submitted as A1. Block Summary: A1 - Frozen section remnant. A2-14 Representative sections from lateral towards medial respectively. The. sections include the entire lesion in relationship to the closest. margins as well as the lateral margin (A2) and the medial margin A14. A15-25 Remaining breast, submitted in toto. See photograph on file in. pathology department for location of blocks. B. "Right breast tissue new posterior margin suture in new margin", received. fresh. A 3.9 x 2.7 x 0.8 cm portion of fibrofatty tissue with a suture on one. surface. The suture surface is marked blue, the specimen is transversely. sectioned and entirely submitted as B1-B4. C. "Right breast tissue new superior margin suture on new margin", received. fresh. A 4.1 x 2.7 x 1.2 cm portion of yellow-white fibrofatty tissue with a. suture present on one surface. The suture surface is marked blue, the. specimen is transversely sectioned and submitted as C1-C4. D. "Right axillary node, suture on apex". received fresh. An 11.2 x 7.5 x 1.2. cm portion of fibrofatty tissue with a suture present at the apex. The. specimen is dissected for lymph node candidates. Block Summary: D1 - 1 Lymph candidate proximal. D2 - 3 lymph node candidates, medial. D3-. 6 Lymph nodes, medial. D4-5 Bisected lymph node candidate. D6. 2 lymph node candidates, distal. D7 - 2 lymph node candidates, distal. /Dr. INTRA OPERATIVE CONSULTATION: A. "Right breast tissue" AF1- invasive carcinoma present. (Dr. DIAGNOSIS: A. "RIGHT BREAST TISSUE" (EXCISIONAL BIOPSY) : INFILTRATING CARCINOMA PRESENT, HISTOLOGIC TYPE DUCTAL. https: N.S.A.B.P. NUCLEAR GRADE: 3 OF 3. N.S.A.B.P. HISTOLOGIC GRADE: 3 OF 3. GROSS TUMOR SIZE: 2.4 x 2.4 X 1.5 CM. SIZE OF INVASIVE COMPONENT: 2. x 1.5 CM. LYMPHATIC/VASCULAR INVASION: ABSENT. MULTIFOCAL TUMOR: ABSENT. IN-SITU CARCINOMA: PRESENT, OCCUPYING LESS THAN 5% OF TUMOR (SEE COMMENT) . TYPE OF IN-SITU CARCINOMA: COMEDO AND CRIBRIFORM. SIZE OF IN-SITU CARCINOMA: APPROXIMATELY 4.8 CM, SEE COMMENT. EXTENSIVE INTRADUCTAL COMPONENT: ABSENT. STATUS OF NON-NEOPLASTIC BREAST TISSUE: BENIGN FIBROCYSTIC CHANGES. SIZE OF BIOPSY: 6.8 x 5.2 X 3.4 CM. MICROCALCIFICATIONS ABSENT. SURGICAL MARGIN STATUS: NEGATIVE (CLOSEST MARGIN 3 MM TO DCIS) . ESTROGEN/PROGESTERONE RECEPTOR AND CELL CYCLE ANALYSIS: PENDING. METHODOLOGY: IMMUNOHISTOCHEMISTRY, PARAFFIN BLOCK A6. RESULTS WILL BE ISSUED IN AN ADDENDUM. COMMENT: Although there is very little in-situ carcinoma within the invasive. tumor mass, there is a large area of DCIS adjacent to the tumor, extending in. a medial direction to near the medial margin. Based on the number of slides. involved, the DCIS involves an area of approximately 4.8 cm in largest. dimension. B. "RIGHT BREAST TISSUE, NEW POSTERIOR MARGIN" (RE-EXCISION) : BREAST TISSUE, NO EVIDENCE OF MALIGNANCY. C. "RIGHT BREAST TISSUE, NEW SUPERIOR MARGIN" (RE-EXCISION). BREAST TISSUE, NO EVIDENCE OF MALIGNANCY. D. "RIGHT AXILLARY LYMPH NODES" (DISSECTION). METASTATIC ADENOCARCINOMA IN TWO OF FOURTEEN AXILLARY LYMPH NODES (2/14). SIZE OF LARGEST METASTASIS: 1.0 CM. EXTRACAPSULAR EXTENSION: ABSENT. I certify that I personally conducted the diagnostic evaluation of the above. specimen (s) and have rendered the above diagnosis (es) . M.D. Page #. ADDENDUM 1: Tissue was sent to the. for assay of the estrogen. and. progesterone receptors. The estrogen receptor activity was judged to be. negative with an estimated FMOL value of 0. The progesterone receptor activity. was judged as negative with an estimated FMOL of value of 0. Please refer to. for a complete report. I certify that I personally conducted the diagnostic evaluation of the above. specimen (s) and have rendered the above diagnosis (es). M.D. Page #. https://. ADDENDUM 2: This addendum is issued to report the results of an additional study. The. previous diagnoses are unchanged. An immunostain for HER2/neu shows moderate. (2+) membrane staining in approximately 50-75% of the tumor cells and is. interpreted as POSITIVE for HER2/neu overexpression. METHODOLOGY: Immunostaining for HER2/neu (c-erbB-2) oncoprotein is performed on recut. sections of Block A6. The immunostaining is done using DAKO rabbit anti-human. c-erbB-2 oncoprotein which is an affinity-isolated antibody. product. number. The immunostaining is performed after antigen retrieval by. heating the unstained sections at 95 degrees centigrade for 20 minutes in 10. mM citrate buffer, pH 6.0. The primary antibody is used at a dilution of. 1:1500 (manual staining) or 1:2000 (autostainer), with an incubation for one. hour at 37 degrees centigrade. The Histostain Plus kit. is used as the detection system. I certify that I personally conducted the diagnostic evaluation of the above. specimen (s) and have rendered the above diagnosis (es). M.D. Page #. https:

expanded version (tokens=2117) : 
 The breast pathology report reveals the following information:

1. Histological classification: Infiltrating ductal carcinoma (IDC) with subtyping of basal type.

2. Necrosis: No mention of necrosis was noted.

3. Tumor infiltrating lymphocytes: No mention of tumor infiltrating lymphocytes was made.

4. Histological grade: Nuclear grade 3 of 3, Histologic grade 3 of 3.

5. Lymphovascular invasion: Absent.

6. Calcification: Microcalcifications were absent.

7. Receptor status: Estrogen receptor and progesterone receptor activity were negative with an estimated FMOL value of 0. HER2/neu shows moderate (2+) membrane staining in approximately 50-75% of the tumor cells and is interpreted as POSITIVE for HER2/neu overexpression.

8. Ancillary testing results: IHC assay for estrogen and progesterone receptors was negative. Immunostain for HER2/neu was positive.

Additional notes:

1. Gross tumor size: 2.4 x 2.4 X 1.5 cm. Size of invasive component: 2. x 1.5 cm.

2. In-situ carcinoma: Present, occupying less than 5% of tumor. The type of in-situ carcinoma is comedo and cribriform. The size of in-situ carcinoma is approximately 4.8 cm.

3. Surgical margin status: Negative (

prompt : Please generate a succinct report in 75 words from the above information. Exclude any filler words or sentences. If something is not mentioned or specified, exclude it from the report. Low verbosity.

final output (tokens=2295) : 
 The report indicates the presence of invasive ductal carcinoma in basal subtype without necrosis, lymphovascular invasion or microcalcifications. The nuclear and histological grade is 3 out of 3. Estrogen and Progesterone receptor activity is negative while HER2/neu is overexpressed. Additional details include a gross tumor size of 2.4x1.5cm with comedo and cribriform in situ carcinoma occupying less than 5%, surgical margin status being negative with the closest margin to DCIS being 3mm away and metastatic adenocarcinoma found in two out of fourteen axillary lymph nodes.

