prompt1 : extract information from  breast pathology report. List the histological classification, i.e. type of cancer or DCIS, subtype, description of any necrosis, any mention of tumor infiltrating lymphocytes,  histological grade, nuclear grade,  lymphovascular invasion, calcification, receptor status, IHC and any other ancillary testing results.  List out and expand the main points.
prompt2 : The report is - Subtype LumA, Laboratory. Collected: xx. F. Received: xx. Reported: xx. Pathologic Interpretation: A. LEFT BREAST NEEDLE LOCALIZATION LUMPECTOMY: INVASIVE LOBULAR CARCINOMA with pleomorphic features, Nottingham grade 2 (3+2+2=7), measuring. 2. cm. PLEOMORPHIC LOBULAR CARCINOMA IN SITU is present. Prior biopsy site present. The invasive carcinoma is 0.1 cm from inferior and lateral margins (green, orange). B. HOT SPOT #1, AXILLAI, CT-xxx: One lymph node, negative for carcinoma (0/1). C. HOT SPOT #1, AXILLAI CT -xxx: One lymph node, negative for carcinoma (0/1). Note: Receptor studies and keratin stains to follow. See Tumor Summary. Surgical Pathology Cancer Case Summary. Procedure: Excision with wire-guided localization. Lymph Node Sampling: Sentinel lymph nodes. Specimen Integrity: Single intact specimen (margins can be evaluated). Specimen Size (for excisions less than total mastectomy): Greatest dimension: 5 cm. Additional dimensions: 4.5 x 3.5 cm. Specimen Laterality: Left. Tumor Size: Size of Largest Invasive Carcinoma: Greatest dimension of largest focus of invasion: 2 cm. Tumor Focality: Single focus of invasive carcinoma. Macroscopic and Microscopic Extent of Tumor: Skin: Skin is not present. Skeletal Muscle: No skeletal muscle present. Ductal Carcinoma in Situ (DCIS): No DCIS is present. Lobular Carcinoma in Situ (LCIS): Present (pleomorphic type). Histologic Type of Invasive Carcinoma: Invasive lobular carcinoma (pleomorphic type). Histologic Grade: Nottingham Histologic Score: Glandular (Acinar)/Tubular Differentiation. Score 3: < 10% of tumor area forming glandular/tubular structures. Nuclear Pleomorphism. Score 2: Cells larger than normal with open vesicular nuclei, visible nucleoli, and moderate. variability in both size and shape. Mitotic Count: Score 2. Overall Grade: Grade 2. Margins: Margins uninvolved by invasive carcinoma. Distance from closest margin: 1 mm. Distance from superior margin: > 5 mm. Distance from inferior margin: 1 mm. Distance from anterior margin: > 5 mm. Distance from posterior margin: > 5 mm. Distance from medial margin: 4 mm. Distance from lateral margin: 1 mm. Treatment Effect: Response to Presurgical (Neoadjuvant) Therapy: In the Breast: No known presurgical therapy. Lymph-Vascular Invasion: Not identified. Lymph Nodes: Number of sentinel lymph nodes examined: 2. Total number of lymph nodes examined (sentinel and nonsentinel): 2. Number of lymph nodes with macrometastases (> 0.2 cm): 0. Number of lymph nodes with micrometastases (> 0.2 mm to 0.2 cm and/or > 200 cells): 0. Number of lymph nodes with isolated tumor cells (s 0.2 mm and S 200 cells): 0. Method of Evaluation of Sentinel Lymph Nodes: Hematoxylin and eosin (H&E), one level. Pathologic Staging (pTNM): Primary Tumor (pT): pT2: Tumor > 20 mm but 50 mm in greatest dimension. Regional Lymph Nodes (pN): pNO: No regional lymph node metastasis identified histologically. Distant Metastasis (pM): Not applicable. Ancillary Studies (performed on another specimen: xxxx): Estrogen Receptor: POSITIVE (> 50%). Progesterone Receptor: NEGATIVE (less than 1% immunoreactive cells present). HER2/neu Immunoperoxidase Studies: NEGATIVE (CISH: NOT AMPLIFIED). NOTE: Some immunohistochemical antibodies are analyte specific reagents (ASRs) validated by our laboratory (Her 2, Parvo, H. pylori, HBcore). These ASRs are clinically. useful indicators that do not require FDA approval. These clones are used: ID5=ER, PgR 636=PR, A485=HER2, H-11=EGFR, CCH2/DDG9=CMV, F39.4 1=AR and HPV. ISH. Allimmunohistochemical stains are used with formalin or molecular fixed, paraffin embedded tissue. Detection is by LSAB. The results are read by a pathologist as positive. or negative. Procedures/Addenda. Addendum. Date Complete: xx. Addendum Diagnosis. A. LEFT BREAST NEEDLE LOCALIZATION LUMPECTOMY: Immunohistochemical studies were performed on formalin fixed tissue with the following results for [invasive. carcinoma/DCIS/metastatic carcinoma] (block xx): Estrogen receptor. POSITIVE ( > 90%). Progesterone receptor. PgR 636. POSITIVE (1-10%). HER-2/neu (c-erb-B2). NEGATIVE 0. B. HOT SPOT #1, AXILLA I, CT-xx: Immunohistochemical studies were performed on formalin fixed tissue with the following results for metastatic. carcinoma (block B): Keratin: NEGATIVE (see note). Note: A single cell that appears to be keratin positive is present in the subcapsular space. However, the nuclear size. and morphology of this cell is different than the primary tumor cells. Selected slides were reviewed with Dr. XX and. concurs with the diagnosis. C. HOT SPOT #1, AXILLAI CT -xx: Immunohistochemical studies were performed on formalin fixed tissue with the following results for metastatic. carcinoma (C): Keratin: NEGATIVE. Interpretation Guidelines: For hormone receptor immunohistochemical analysis, the percent of immunoreactive. nuclei in the invasive or in-situ carcinoma is assessed manually by light microscopic examination and reported as. follows: Positive: greater than or equal to 1 percent of nuclei immunoreactive. Negative: less than 1 percent of nuclei immunoreactive. Non-neoplastic mammary epithelial cells are immunoreactive for estrogen and progesterone receptors (internal. control). For HER2/neu immunohistochemical analysis, the cell membrane staining is assessed manually by light microscopic. examination. Cytoplasmic immunoreactivity alone is scored as a negative result. Reference #1: XX. Reference #2: XX. Clinical History: Infiltrating lobular cancer in left breast. Please evaluate margins of lumpectomy. If sentinel nodes are negative, do. immunohistochemistry. Specimen(s) Received/Processing Information: Fee Codes: A: Left breast lumpectomy, 1 suture superficial margin, 2 suture medial, 3 suture. inferior H&E, Initial x 1, H&E, Initial x 1, H&E, Initial x 1, H&E, Initial x 1, H&E, Initial x 1,. H&E, Initial x 1, H&E, Initial x 1, H&E, Initial x 1, H&E, Initial x 1, Estrogen Receptor (ER) x 1,. Progesterone Receptor x 1, CERbB2, HER2/neu x 1. B: Hot spot #1, axilla I, CT-356 H&E, Initial x 1, unstained x 1, unstained x 1, unstained x. 1, unstained x 1, Desmin 33 x 1. C: Hot spot #1, axilla I CT -473 H&E, Initial x 1, unstained x 1, unstained x 1, unstained x. 1, unstained x 1, Cytokeratin Cocktail (KER) x 1. Gross Description: A. Received fresh and labeled "Left breast lumpectomy" is a yellow-tan irregular-shaped lumpectomy,. measuring 5.0 x 4.5 x 3.5 cm and weighing 35.0 grams. The specimen is inked as follows: superior. margin. inked blue, inferior margin inked green, medial margin inked red, lateral margin inked orange,. anterior/superficial margin inked yellow and deep margin inked black. Sections reveal an ill-defined area with. firm to hard consistency, 2.0 x 2.0 x 1.5 cm. This area is located toward the medial to posterior resection. margin at 0.2 to 0.3 cm from the deep resection margin (nearest), 0.3 cm from the inferior resection margin,. 3.0 cm from lateral resection margin, 2.0 cm from the superior resection margin, 1.0 cm from the superficial. resection margin. The remainder of the specimen is homogeneous, yellow-tan, grossly unremarkable. adipose tissue. No other suspicious lesions are present. The specimen is submitted in nine cassettes, as. follows: Cassette #1-3: Tissue with clip in toto. Cassette #4: Perpendicular section superior margin. Cassette #5: Perpendicular section inferior margin. Cassette #6: Perpendicular section medial margin. Cassette #7: Perpendicular section lateral margin. Cassette #8: Perpendicular section superficial margin. Cassette #9: Perpendicular section deep margin. B. Received in formalin and labeled "Hot spot #1, axilla I, ct xx" is a yellow-tan irregular-shaped soft tissue. fragment, 3.5 x 3.0 x 1.0 cm. Sections reveal one lymph node, 1.5 x 1.0 x 1.0 cm. The lymph node is bisected and. submitted in toto in one. cassette. C. Received in formalin and labeled "Hot spot #1, axilla I, ct xx" is a yellow-tan irregular-shaped soft tissue. fragment, 2.8 x 2.0 x 1.0 cm. Sections reveal one lymph node, 1.5 x 1.0 x 1.0 cm. the lymph node is bisected and. submitted in toto in one cassette.

expanded version (tokens=2517) : 
 Histological classification: 
- Invasive lobular carcinoma (pleomorphic type) 
- Pleomorphic lobular carcinoma in situ 
- No DCIS present 
- Lobular carcinoma in situ (pleomorphic type)

Subtype: LumA 

Necrosis: Not identified 

Tumor infiltrating lymphocytes: Not identified 

Histological grade: Nottingham Histologic Score grade 2 (3+2+2=7) 

Nuclear grade: Score 2

Lymphovascular invasion: Not identified 

Calcification: Not mentioned 

Receptor status: 
- Estrogen receptor: Positive (>50%) 
- Progesterone receptor: Negative (less than 1% immunoreactive cells present) 
- HER2/neu: Negative (CISH: NOT AMPLIFIED) 

IHC: Estrogen receptor, Progesterone receptor, HER2/neu 

Ancillary Testing Results: None mentioned.

prompt : Please generate a succinct report in 75 words from the above information. Exclude any filler words or sentences. If something is not mentioned or specified, exclude it from the report. Low verbosity.

final output (tokens=2685) : 
 Left breast needle localization lumpectomy report reveals invasive pleomorphic lobular carcinoma (1 focus, 2 cm), with pleomorphic lobular carcinoma in situ. Nottingham Histologic Score of 2, nuclear grade score of 2 and no lymphovascular invasion or calcification identified. Estrogen receptor was positive (>50%), progesterone receptor was negative (1% immunoreactive cells present), HER2/neu was negative. No tumor infiltrating lymphocytes and no necrosis were identified. Lymph node analysis showed no malignancy noted microscopically in the two examined sentinel nodes.

