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[bibtex]@InProceedings{Fan_2024_WACV, author = {Fan, Quanfu and Li, Yilai and Yao, Yuguang and Cohn, John and Liu, Sijia and Xu, Ziping and Vos, Seychelle and Cianfrocco, Michael}, title = {CryoRL: Reinforcement Learning Enables Efficient Cryo-EM Data Collection}, booktitle = {Proceedings of the IEEE/CVF Winter Conference on Applications of Computer Vision (WACV)}, month = {January}, year = {2024}, pages = {7892-7902} }
CryoRL: Reinforcement Learning Enables Efficient Cryo-EM Data Collection
Abstract
Single-particle cryo-electron microscopy (cryo-EM) has become one of the mainstream structural biology techniques because of its ability to determine high-resolution structures of dynamic bio-molecules. However, cryo-EM data acquisition remains expensive and labor-intensive, requiring substantial expertise. Structural biologists need a more efficient and objective method to collect the best data in a limited time frame. We formulate the cryo-EM data collection task as an optimization problem in this work. The goal is to maximize the total number of good images taken within a specified period. We show that reinforcement learning offers an effective way to plan cryo-EM data collection, successfully navigating heterogenous cryo-EM grids. The approach we developed, cryoRL, demonstrates better performance than average users for data collection under similar settings.
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