Feasibility of Federated Learning from Client Databases with Different Brain Diseases and MRI Modalities

Felix Wagner, Wentian Xu, Pramit Saha, Ziyun Liang, Daniel Whitehouse, David Menon, Virginia Newcombe, Natalie Voets, J. Alison Noble, Konstantinos Kamnitsas; Proceedings of the Winter Conference on Applications of Computer Vision (WACV), 2025, pp. 357-367

Abstract


Segmentation models for brain lesions in MRI are commonly developed for a specific disease and trained on data with a predefined set of MRI modalities. Such models cannot segment the disease using data with a different set of MRI modalities nor can they segment other types of diseases. Moreover this training paradigm prevents a model from using the advantages of learning from heterogeneous databases that may contain scans and segmentation labels for different brain pathologies and diverse sets of MRI modalities. Additionally the confidentiality of patient data often prevents central data aggregation necessitating a decentralized approach. Is it feasible to use Federated Learning (FL) to train a single model on client databases that contain scans and labels of different brain pathologies and diverse sets of MRI modalities? We demonstrate promising results by combining appropriate simple and practical modifications to the model and training strategy: Designing a model with input channels that cover the whole set of modalities available across clients training with random modality drop and exploring the effects of feature normalization methods. Evaluation on 7 brain MRI databases with 5 different diseases shows that this FL framework can train a single model that achieves very promising results in segmenting all disease types seen during training. Importantly it can segment these diseases in new databases that contain sets of modalities different from those in training clients. These results demonstrate for the first time the feasibility and effectiveness of using FL to train a single 3D segmentation model on decentralised data with diverse brain diseases and MRI modalities a necessary step towards leveraging heterogeneous real-world databases. Code: https://github.com/FelixWag/FedUniBrain

Related Material


[pdf] [supp] [arXiv]
[bibtex]
@InProceedings{Wagner_2025_WACV, author = {Wagner, Felix and Xu, Wentian and Saha, Pramit and Liang, Ziyun and Whitehouse, Daniel and Menon, David and Newcombe, Virginia and Voets, Natalie and Noble, J. Alison and Kamnitsas, Konstantinos}, title = {Feasibility of Federated Learning from Client Databases with Different Brain Diseases and MRI Modalities}, booktitle = {Proceedings of the Winter Conference on Applications of Computer Vision (WACV)}, month = {February}, year = {2025}, pages = {357-367} }