Multimodal Whole Brain Registration: MRI and High Resolution Histology

Maryana Alegro, Edson Amaro-Jr, Burlen Loring, Helmut Heinsen, Eduardo Alho, Lilla Zollei, Daniela Ushizima, Lea T. Grinberg; Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition (CVPR) Workshops, 2016, pp. 194-202


Three-dimensional brain imaging through cutting-edge MRI technology allows assessment of physical and chemical tissue properties at sub-millimeter resolution. In order to improve brain understanding as part of diagnostic tasks using MRI images, other imaging modalities to obtain deep cerebral structures and cytoarchitectural boundaries have been investigated. Under availability of postmortem samples, the fusion of MRI to brain histology supports more accurate description of neuroanatomical structures since it preserves microscopic entities and reveal fine anatomical details, unavailable otherwise. Nonetheless, histological processing causes severe tissue deformation and loss of the brain original 3D conformation, preventing direct comparisons between MRI and histology. This paper proposes an interactive computational pipeline designed to register multimodal brain data and enable direct histology-MRI correlation. Our main contribution is to develop schemes for brain data fusion, distortion corrections, using appropriate diffeomorphic mappings to align the 3D histological and MRI volumes. We describe our pipeline and preliminary developments of scalable processing schemes for high-resolution images. Tests consider a postmortem human brain, and include qualitatively and quantitatively results, such as 3D visualizations and the Dice coefficient (DC) between brain structures. Preliminary results show promising DC values when comparing our scheme results to manually labeled neuroanatomical regions defined by a neurosurgeon on MRI and histology data sets. DC was computed for the left caudade gyrus (LC), right hippocampus (RH) and lateral ventricles (LV).

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author = {Alegro, Maryana and Amaro-Jr, Edson and Loring, Burlen and Heinsen, Helmut and Alho, Eduardo and Zollei, Lilla and Ushizima, Daniela and Grinberg, Lea T.},
title = {Multimodal Whole Brain Registration: MRI and High Resolution Histology},
booktitle = {Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition (CVPR) Workshops},
month = {June},
year = {2016}