%PDF-1.3 1 0 obj << /Kids [ 3 0 R 4 0 R 5 0 R 6 0 R 7 0 R 8 0 R 9 0 R 10 0 R 11 0 R ] /Type /Pages /Count 9 >> endobj 2 0 obj << /Title (3D Cell Nuclear Morphology\072 Microscopy Imaging Dataset and Voxel\055Based Morphometry Classification Results) /Producer (PyPDF2) /Author (Alexandr A\056 Kalinin\054 Ari Allyn\055Feuer\054 Alex Ade\054 Gordon\055Victor Fon\054 Walter Meixner\054 David Dilworth\054 Jeffrey R\056 de Wet\054 Gerald A\056 Higgins\054 Gen Zheng\054 Amy Creekmore\054 John W\056 Wiley\054 James E\056 Verdone\054 Robert W\056 Veltri\054 Kenneth J\056 Pienta\054 Donald S\056 Coffey\054 Brian D\056 Athey\054 Ivo D\056 Dinov) /Subject (2018 IEEE Conference on Computer Vision and Pattern Recognition Workshops) >> endobj 3 0 obj << /Parent 1 0 R /Rotate 0 /Type /Page /Contents 13 0 R /Resources << /XObject << /x8 14 0 R /x6 17 0 R /x12 20 0 R /x10 23 0 R >> /ExtGState << /s9 26 0 R /s11 29 0 R /a0 << /CA 1 /ca 1 >> /R14 32 0 R /s5 33 0 R /s7 36 0 R >> /Font << /F2 39 0 R /R29 40 0 R /F1 43 0 R /R15 44 0 R /R17 48 0 R /R21 52 0 R /R19 56 0 R /R23 59 0 R /R25 63 0 R /R27 66 0 R >> /ProcSet [ /ImageC /Text /PDF /ImageI /ImageB ] >> /MediaBox [ 0 0 612 792 ] /Annots [ 70 0 R 71 0 R 72 0 R 73 0 R 74 0 R ] >> endobj 4 0 obj << /Parent 1 0 R /Rotate 0 /Type /Page /Contents 75 0 R /Resources << /ExtGState << /R14 32 0 R >> /Font << /F2 76 0 R /F1 77 0 R /R25 63 0 R /R15 44 0 R /R17 48 0 R >> /ProcSet [ /ImageC /Text /PDF /ImageI /ImageB ] >> /MediaBox [ 0 0 612 792 ] /Annots [ 78 0 R 79 0 R 80 0 R 81 0 R 82 0 R 83 0 R 84 0 R 85 0 R 86 0 R 87 0 R 88 0 R 89 0 R 90 0 R 91 0 R 92 0 R 93 0 R 94 0 R 95 0 R 96 0 R 97 0 R 98 0 R 99 0 R 100 0 R ] >> endobj 5 0 obj << /Parent 1 0 R /Rotate 0 /Contents 101 0 R /Resources << /XObject << /R72 102 0 R /R71 103 0 R >> /ExtGState << /R14 32 0 R >> /Font << /R79 104 0 R /R73 107 0 R /R77 110 0 R /R75 114 0 R /F2 118 0 R /F1 119 0 R /R15 44 0 R /R17 48 0 R /R23 59 0 R /R81 120 0 R >> /ProcSet [ /Text /ImageC /ImageB /PDF /ImageI ] >> /Group 123 0 R /MediaBox [ 0 0 612 792 ] /Annots [ 124 0 R 125 0 R 126 0 R 127 0 R 128 0 R ] /Type /Page >> endobj 6 0 obj << /Parent 1 0 R /Rotate 0 /Contents 129 0 R /Resources << /XObject << /R96 130 0 R /R97 131 0 R >> /ExtGState << /R14 32 0 R >> /Font << /F2 132 0 R /F1 133 0 R /R15 44 0 R /R17 48 0 R >> /ProcSet [ /Text /ImageC /ImageB /PDF /ImageI ] >> /Group 123 0 R /MediaBox [ 0 0 612 792 ] /Annots [ 134 0 R 135 0 R 136 0 R 137 0 R 138 0 R 139 0 R 140 0 R ] /Type /Page >> endobj 7 0 obj << /Parent 1 0 R /Rotate 0 /Type /Page /Contents 141 0 R /Resources << /ExtGState << /R14 32 0 R >> /Font << /R73 107 0 R /R77 110 0 R /R75 114 0 R /F2 142 0 R /F1 143 0 R /R15 44 0 R /R17 48 0 R >> /ProcSet [ /ImageC /Text /PDF /ImageI /ImageB ] >> /MediaBox [ 0 0 612 792 ] /Annots [ 144 0 R 145 0 R 146 0 R 147 0 R 148 0 R 149 0 R 150 0 R 151 0 R 152 0 R 153 0 R 154 0 R 155 0 R 156 0 R ] >> endobj 8 0 obj << /Parent 1 0 R /Rotate 0 /Contents 157 0 R /Resources << /XObject << /R127 158 0 R /R130 159 0 R /R132 161 0 R /R131 162 0 R /R129 160 0 R /R128 163 0 R >> /ExtGState << /R14 32 0 R >> /Font << /R73 107 0 R /R77 110 0 R /R75 114 0 R /F2 164 0 R /F1 165 0 R /R15 44 0 R /R17 48 0 R >> /ProcSet [ /Text /ImageC /ImageB /PDF /ImageI ] >> /Group 123 0 R /MediaBox [ 0 0 612 792 ] /Annots [ 166 0 R 167 0 R 168 0 R 169 0 R 170 0 R ] /Type /Page >> endobj 9 0 obj << /Parent 1 0 R /Rotate 0 /Type /Page /Contents 171 0 R /Resources << /ExtGState << /R14 32 0 R >> /Font << /F2 172 0 R /F1 173 0 R /R15 44 0 R /R17 48 0 R /R73 107 0 R /R25 63 0 R /R77 110 0 R /R75 114 0 R >> /ProcSet [ /ImageC /Text /PDF /ImageI /ImageB ] >> /MediaBox [ 0 0 612 792 ] /Annots [ 174 0 R 175 0 R 176 0 R 177 0 R 178 0 R 179 0 R 180 0 R 181 0 R 182 0 R 183 0 R 184 0 R ] >> endobj 10 0 obj << /Parent 1 0 R /Rotate 0 /Type /Page /Contents 185 0 R /Resources << /ExtGState << /R14 32 0 R >> /Font << /F2 186 0 R /F1 187 0 R /R15 44 0 R /R27 66 0 R /R17 48 0 R >> /ProcSet [ /ImageC /Text /PDF /ImageI /ImageB ] >> /MediaBox [ 0 0 612 792 ] /Annots [ ] >> endobj 11 0 obj << /Parent 1 0 R /Rotate 0 /Type /Page /Contents 188 0 R /Resources << /ExtGState << /R14 32 0 R >> /Font << /F2 189 0 R /F1 190 0 R /R27 66 0 R /R17 48 0 R >> /ProcSet [ /ImageC /Text /PDF /ImageI /ImageB ] >> /MediaBox [ 0 0 612 792 ] /Annots [ ] >> endobj 12 0 obj << /Type /Catalog /Pages 1 0 R >> endobj 13 0 obj << /Length 14405 >> stream q q q 0.1 0 0 0.1 0 0 cm /R14 gs 0 g q 10 0 0 10 0 0 cm BT /R15 14.3462 Tf 1 0 0 1 63.8 675.067 Tm [ (3D) -249.998 (Cell) -249.994 (Nuclear) -249.995 (Mor) 9.9988 (phology\072) -309.998 (Micr) 18.0099 (oscopy) -250.007 (Imaging) -249.995 (Dataset) -250.002 (and) -249.991 (V) 99.9931 (oxel\055Based) ] TJ 123.505 -17.9332 Td [ (Mor) 9.99795 (phometry) -249.993 <436c6173736902636174696f6e> -250 (Results) ] TJ /R17 11.9552 Tf -112.22 -37.8578 Td [ (Ale) 15 (xandr) -250.013 (A\056) -250.01 (Kalinin) ] TJ /R19 7.9701 Tf 97.7687 4.33867 Td [ (1) -0.29866 ] TJ /R21 7.9701 Tf 4.23398 0 Td [ (\073) -0.09955 ] TJ /R19 7.9701 Tf 2.35195 0 Td [ (2) -0.29866 ] TJ /R17 11.9552 Tf 4.7332 -4.33867 Td [ (\054) -250.012 (Ari) -249.993 (Allyn\055Feuer) ] TJ /R19 7.9701 Tf 83.3379 4.33867 Td [ (1) -0.30019 ] TJ /R17 11.9552 Tf 4.7332 -4.33867 Td [ (\054) -250.012 (Ale) 15 (x) -250.002 (Ade) ] TJ /R19 7.9701 Tf 51.9449 4.33867 Td [ (1) -0.30019 ] TJ /R17 11.9552 Tf 4.73203 -4.33867 Td [ (\054) -250.012 (Gordon\055V) 59.9835 (ictor) -250.004 (F) 15.0137 (on) ] TJ /R19 7.9701 Tf 97.7211 4.33867 Td [ (1) -0.30019 ] TJ /R17 11.9552 Tf 4.73164 -4.33867 Td [ (\054) -250.01 (W) 79.9984 (alter) -250.002 (Meixner) ] TJ /R19 7.9701 Tf 81.0441 4.33867 Td [ (1) -0.30019 ] TJ /R17 11.9552 Tf 4.73203 -4.33867 Td (\054) Tj -434.438 -13.9473 Td [ (Da) 19.9899 (vid) -250.003 (Dil) 9.98499 (w) 10 (orth) ] TJ /R19 7.9701 Tf 74.8988 4.33828 Td [ (1) -0.29866 ] TJ /R17 11.9552 Tf 4.73203 -4.33828 Td [ (\054) -250.012 (Jef) 24.9885 (fre) 14.9943 (y) -250 (R\056) -249.987 (de) -250.008 (W) 80 (et) ] TJ /R19 7.9701 Tf 88.8621 4.33828 Td [ (1) -0.30019 ] TJ /R17 11.9552 Tf 4.73203 -4.33828 Td [ (\054) -250.012 (Gerald) -249.987 (A\056) -250.01 (Higgins) ] TJ /R19 7.9701 Tf 93.9668 4.33828 Td [ (1) -0.30019 ] TJ /R17 11.9552 Tf 4.7332 -4.33828 Td [ (\054) -250.012 (Gen) -250.008 (Zheng) ] TJ /R19 7.9701 Tf 59.4277 4.33828 Td [ (3) -0.30019 ] TJ /R17 11.9552 Tf 4.7332 -4.33828 Td [ (\054) -250.01 (Amy) -250.002 (Creekmore) ] TJ /R19 7.9701 Tf 85.993 4.33828 Td [ (3) -0.30019 ] TJ /R17 11.9552 Tf 4.73203 -4.33828 Td (\054) Tj -390.63 -13.948 Td [ (John) -250.008 (W) 91.9908 (\056) -250.012 (W) 40.0063 (ile) 15.0076 (y) ] TJ /R19 7.9701 Tf 70.2969 4.33828 Td [ (3) -0.29866 ] TJ /R17 11.9552 Tf 4.73203 -4.33828 Td [ (\054) -250.012 (James) -250.01 (E\056) -250.016 (V) 110.996 (erdone) ] TJ /R19 7.9701 Tf 91.3012 4.33828 Td [ (4) -0.30019 ] TJ /R17 11.9552 Tf 4.73203 -4.33828 Td [ (\054) -250.012 (Robert) -250 (W) 91.9918 (\056) -250.012 (V) 110.996 (eltri) ] TJ /R19 7.9701 Tf 84.2348 4.33828 Td [ (4) -0.30019 ] TJ /R17 11.9552 Tf 4.7332 -4.33828 Td [ (\054) -250.012 (K) 24.9977 (enneth) -249.997 (J\056) -249.997 (Pienta) ] TJ /R19 7.9701 Tf 89.6859 4.33828 Td [ (4) -0.30019 ] TJ /R17 11.9552 Tf 4.73281 -4.33828 Td (\054) Tj -310.048 -13.9477 Td [ (Donald) -249.988 (S\056) -249.993 (Cof) 24.9957 (fe) 15.0076 (y) ] TJ /R19 7.9701 Tf 83.5309 4.33867 Td [ (4) -0.30019 ] TJ /R17 11.9552 Tf 4.73203 -4.33867 Td [ (\054) -250.012 (Brian) -249.989 (D\056) -250.01 (Athe) 14.9892 (y) ] TJ /R19 7.9701 Tf 79.1781 4.33867 Td [ (1) -0.30019 ] TJ /R21 7.9701 Tf 4.23477 0 Td [ (\073) -0.10109 ] TJ /R19 7.9701 Tf 2.35195 0 Td [ (5) -0.30019 ] TJ /R17 11.9552 Tf 4.73203 -4.33867 Td [ (\054) -250.012 (Iv) 20.0047 (o) -250.002 (D\056) -250.01 (Dino) 14.9851 (v) ] TJ /R19 7.9701 Tf 68.9809 4.33867 Td [ (1) -0.30019 ] TJ /R21 7.9701 Tf 4.23516 0 Td [ (\073) -0.09802 ] TJ /R19 7.9701 Tf 2.35195 0 Td [ (2) -0.30019 ] TJ /R21 7.9701 Tf 4.23398 0 Td [ (\073) -0.09802 ] TJ /R19 7.9701 Tf 2.35312 0 Td [ (5) -0.30019 ] TJ -273.739 -19.6168 Td [ (1) -0.29866 ] TJ /R17 11.9552 Tf 4.73281 -4.33906 Td [ (Department) -250 (of) -250.014 (Computational) -250.004 (Medicine) -250.014 (and) -249.987 (Bioinformatics\054) ] TJ -8.16484 -13.9469 Td [ (Uni) 24.9946 (v) 14.9862 (ersity) -249.989 (of) -250.014 (Michig) 4.99096 (an) -250.008 (Medical) -250.002 (School\054) -249.993 (Ann) -250.01 (Arbor) 40.0094 (\054) -250.012 (MI) -249.997 (48109) ] TJ /R19 7.9701 Tf -75.65 -9.61016 Td [ (2) -0.30019 ] TJ /R17 11.9552 Tf 4.73203 -4.33789 Td [ (Statistics) -250.01 (Online) -250 (Computational) -250.004 (Resource) -250.01 (\050SOCR\051\054) -250.004 (Health) -249.997 (Beha) 19.9945 (vior) -249.983 (and) -249.985 (Biological) -250.01 (Sciences\054) ] TJ 64.773 -13.948 Td [ (Uni) 24.9946 (v) 14.9862 (ersity) -249.989 (of) -250.015 (Michig) 4.99096 (an) -250.008 (School) -250.004 (of) -250.014 (Nursing\054) -250.002 (Ann) -250.01 (Arbor) 40.0094 (\054) -250.012 (MI) -249.997 (48109) ] TJ /R19 7.9701 Tf 1.49609 -9.60898 Td [ (3) -0.29866 ] TJ /R17 11.9552 Tf 4.73164 -4.33828 Td [ (Di) 25.0059 (vision) -249.989 (of) -250.015 (Gastroenterology) 65.0112 (\054) -250.012 (Department) -250 (of) -250.014 (Internal) -250.006 (Medicine\054) ] TJ -0.08281 -13.9477 Td [ (Uni) 24.9946 (v) 14.9862 (ersity) -249.989 (of) -250.014 (Michig) 4.99096 (an) -250.008 (Medical) -250.002 (School\054) -249.993 (Ann) -250.01 (Arbor) 40.0094 (\054) -250.012 (MI) -249.997 (48109) ] TJ /R19 7.9701 Tf -27.0469 -9.60898 Td [ (4) -0.29866 ] TJ /R17 11.9552 Tf 4.73203 -4.33906 Td [ (Department) -250 (of) -250.015 (Urology) 65.0051 (\054) -250.012 (The) -250.014 (James) -250.01 (Buchanan) -250.002 (Brady) -250.01 (Urological) -249.993 (Institute\054) ] TJ 55.4598 -13.948 Td [ (Johns) -249.993 (Hopkins) -250.01 (Uni) 24.9957 (v) 14.9851 (ersity) 64.9887 (\054) -250.012 (Baltimore\054) -250.004 (MD) -249.983 (21218) ] TJ /R19 7.9701 Tf 3.77305 -9.60898 Td [ (5) -0.29866 ] TJ /R17 11.9552 Tf 4.7332 -4.33828 Td [ (Michig) 4.99096 (an) -250.008 (Institute) -250.016 (for) -249.995 (Data) -249.995 (Science) -250.006 (\050MID) 40.0033 (AS\051\054) ] TJ -3.96328 -13.9477 Td [ (Uni) 24.9946 (v) 14.9851 (ersity) -249.989 (of) -250.014 (Michig) 4.99096 (an\054) -249.997 (Ann) -250.01 (Arbor) 40.0094 (\054) -250.012 (MI) -250 (48109) ] TJ /R23 8.9664 Tf -26.2168 -16.782 Td [ (f) -0.8999 ] TJ /R25 8.9664 Tf 4.60781 0 Td (akalinin\054ariallyn\054asade\054gordonvi\054meixner) Tj /R23 8.9664 Tf 215.192 0 Td [ (g) -0.90126 ] TJ /R25 8.9664 Tf 4.60781 0 Td (\100umich\056edu) Tj /R23 8.9664 Tf -251.307 -13.948 Td [ (f) -0.8999 ] TJ /R25 8.9664 Tf 4.60703 0 Td (dilworth\054jrdewet\054gehiggin\054zhenggen\054creekmoa\054jwiley) Tj /R23 8.9664 Tf 268.991 0 Td [ (g) -0.89854 ] TJ /R25 8.9664 Tf 4.6082 0 Td (\100umich\056edu) Tj /R23 8.9664 Tf -232.478 -13.948 Td [ (f) -0.8999 ] TJ /R25 8.9664 Tf 4.6082 0 Td (jverdon1\054rveltri1\054kpienta1\054dcoffey) Tj /R23 8.9664 Tf 182.914 0 Td [ (g) -0.90126 ] TJ /R25 8.9664 Tf 4.60703 0 Td (\100jhmi\056edu) Tj /R23 8.9664 Tf -130.261 -13.9469 Td [ (f) -0.90126 ] TJ /R25 8.9664 Tf 4.6082 0 Td (bleu\054dinov) Tj /R23 8.9664 Tf 53.7977 0 Td [ (g) -0.90126 ] TJ /R25 8.9664 Tf 4.6082 0 Td (\100umich\056edu) Tj /R15 11.9552 Tf -156.225 -41.0473 Td (Abstract) Tj /R27 9.9626 Tf -83.9281 -24.4668 Td [ (Cell) -262.011 (deformation) -261.983 (is) -261.982 (r) 37.0196 (e) 39.9884 (gulated) -262.004 (by) -263.014 (comple) 20.0089 (x) -262 (underlying) -261.998 (bi\055) ] TJ -11.9551 -11.9551 Td [ (olo) 10.0155 (gical) -437.985 (mec) 15.011 (hanisms) -438.008 (associated) -438.007 (with) -438.011 (spatial) -438.003 (and) -437.991 (tempo\055) ] TJ 11.9551 TL T* [ (r) 14.984 (al) -340.99 (morpholo) 10 (gical) -340.982 (c) 15.0122 (hang) 10.0179 (es) -341 (in) -340.99 (the) -340.995 (nucleus) -340.982 (that) -341.017 (ar) 36.9865 (e) -341.007 (r) 37.0183 (elated) ] TJ T* [ (to) -322.012 (cell) -321 (dif) 18.0166 (fer) 36.9834 (entiation\054) -338.995 (de) 15.0183 (velopment\054) -340 (pr) 44.9851 (olifer) 15.0073 (ation\054) -339.01 (and) -322.01 (dis\055) ] TJ 11.9559 TL T* [ (ease) 15.0196 (\056) -773.006 (Thus\054) -442.991 (quantitative) -405.017 (analysis) -404.013 (of) -403.999 (c) 15.0122 (hang) 10.0179 (es) -404.989 (in) -403.999 (size) -405.016 (and) ] TJ 11.9551 TL T* [ (shape) -213.987 (of) -215.011 (nuclear) -213.984 (structur) 37.0122 (es) -214.002 (in) -215.011 (3D) -213.996 (micr) 44.9851 (oscopic) -213.984 (ima) 10.013 (g) 10.0032 (es) -214.001 (is) -215.011 (im\055) ] TJ T* [ (portant) -261.994 (not) -262.018 (only) -261.983 (for) -262.016 (in) 40.0056 (vestigating) -261.988 (nuclear) -262.015 (or) 36.9865 (ganization\054) -264.993 (b) 20.0016 (ut) ] TJ T* [ (also) -222.018 (for) -221.984 (detecting) -220.999 (and) -221.987 (tr) 36.9877 (eating) -222.017 (patholo) 9.99833 (gical) -221.983 (conditions) -221.992 (suc) 14.9852 (h) ] TJ T* [ (as) -322.994 (cancer) 111.004 (\056) -529.007 (While) -322.988 (many) -322.996 (ef) 18 (forts) -323.012 (have) -323.004 (been) -323.002 (made) -322.998 (to) -322.993 (de) 15.0171 (velop) ] TJ T* [ (cell) -243.013 (and) -241.984 (nuclear) -242.999 (shape) -241.982 (c) 15.0122 (har) 14.9938 (acteristics) -243.018 (in) -243.006 (2D) -241.991 (or) -243.006 (pseudo\0553D\054) ] TJ 11.9559 TL T* [ (se) 15.0189 (ver) 15.0147 (al) -259.984 (studies) -260.983 (have) -259.995 (sug) 10.0143 (g) 10.0032 (ested) -261.005 (that) -260.011 (3D) -259.988 (morphometric) -261.01 (mea\055) ] TJ 11.9551 TL T* [ (sur) 36.9914 (es) -374.994 (pr) 44.9839 (o) 10.0032 (vide) -374.012 (better) -375.018 (r) 37.0196 (esults) -373.989 (for) -375.017 (nuclear) -373.996 (shape) -375.018 (description) ] TJ T* [ (and) -302.013 (discrimination\056) -466.006 (A) -301.985 (fe) 14.9803 (w) -302.015 (methods) -302.001 (have) -303.006 (been) -301.986 (pr) 44.9851 (oposed) -302.006 (to) ] TJ T* [ (classify) -297.999 (cell) -297.984 (and) -298.014 (nuclear) -298.009 (morpholo) 10 (gical) -298.009 (phenotypes) -298.984 (in) -298.016 (3D\054) ] TJ T* [ (howe) 14.9969 (ver) 110.999 (\054) -370.014 (ther) 36.9877 (e) -345.986 (is) -344.988 (a) -346.016 (lac) 20.004 (k) -345.986 (of) -346.008 (publicly) -345.012 (available) -345.989 (3D) -346.013 (data) -345.999 (for) ] TJ 11.9559 TL T* [ (the) -400.004 (e) 15.0128 (valuation) -400.009 (and) -399.997 (comparison) -400.008 (of) -400 (suc) 14.9852 (h) -400.007 (algorithms\056) -760.01 (This) ] TJ 11.9551 TL T* [ (limitation) -288.009 (becomes) -289.004 (of) -288.018 (gr) 36.9852 (eat) -287.984 (importance) -289.016 (when) -288.011 (the) -287.984 (ability) -289.016 (to) ] TJ T* [ (e) 15.0128 (valuate) -242.017 (dif) 18.0166 (fer) 36.9828 (ent) -241.991 (appr) 44.9937 (oac) 14.984 (hes) -243.011 (on) -241.989 (benc) 15.0183 (hmark) -241.984 (data) -242.016 (is) -243.006 (needed) ] TJ T* [ (for) -241.98 (better) -241.982 (dissemi) 1.01086 (na) -1.00964 (t) 0.98758 (ion) -241.982 (of) -241.987 (the) -241.991 (curr) 36.9865 (ent) -241.991 (state) -240.997 (of) -241.987 (the) -241.991 (art) -241.982 (meth\055) ] TJ T* [ (ods) -419.012 (for) -419.99 (bioima) 9.99098 (g) 10.0032 (e) -418.994 (analysis\056) -817.981 (T) 92 (o) -418.984 (addr) 36.9951 (ess) -420 (this) -419.004 (pr) 44.9851 (oblem\054) -461.984 (we) ] TJ 258.75 251.615 Td [ (pr) 36.9865 (esent) -332.993 (a) -334.018 (dataset) -333.011 (containing) -334.013 (two) -333.018 (dif) 18.0166 (fer) 36.984 (ent) -332.993 (cell) -334.018 (collections\054) ] TJ T* [ (including) -453.02 (original) -451.996 (3D) -453.015 (micr) 44.9827 (oscopic) -453.003 (ima) 10.013 (g) 10.0032 (es) -452.003 (of) -453.013 (cell) -453.018 (nuclei) ] TJ T* [ (and) -358.984 (nucleoli\056) -635.982 (In) -358.996 (addition\054) -386.004 (we) -358.009 (perform) -359.009 (a) -358.994 (baseline) -359.014 (e) 15.0122 (valua\055) ] TJ T* [ (tion) -262.99 (of) -261.983 (a) -263.01 (number) -262.015 (of) -263.003 (popular) -263.015 <636c6173736902636174696f6e> -262.015 (algorithms) -262.995 (using) ] TJ T* [ (2D) -392.986 (and) -393.018 (3D) -392.986 (voxel\055based) -392.981 (morphometric) -392.988 (measur) 36.9938 (es\056) -739.009 (T) 92 (o) -392.988 (ac\055) ] TJ 11.9559 TL T* [ (count) -296.012 (for) -296.012 (batc) 14.9901 (h) -295.985 (ef) 18 (fects\054) -308.012 (while) -296 (enabling) -295.995 (calculations) -297 (of) -296.019 (A) 49.9966 (U\055) ] TJ 11.9551 TL T* [ (R) 39.9982 (OC) -205.988 (and) -205.99 (A) 49.9966 (UPR) -205.995 (performance) -206.015 (metrics\054) -214.998 (we) -205.995 (pr) 44.9827 (opose) -207.01 (a) -206 <73706563690263> ] TJ T* [ (cr) 45.0145 (oss\055validation) -395.008 (sc) 15.0196 (heme) -394.993 (that) -393.988 (we) -394.983 (compar) 36.9938 (e) -394.998 (with) -394.998 (commonly) ] TJ T* [ (used) -376.984 (k\055fold) -377.018 (cr) 45.0145 (oss\055validation\056) -690.997 (Original) -376.991 (and) -376.981 (derived) -376.986 (ima) 10.013 (g\055) ] TJ T* [ (ing) -366 (data) -367.015 (ar) 36.9865 (e) -365.983 (made) -366.99 (publicly) -365.988 (available) -365.983 (on) -366.988 (the) -366.008 (pr) 44.9827 (oject) -366.988 (web\055) ] TJ T* [ (pa) 10.0081 (g) 10.0032 (e\072) ] TJ /R29 9.9626 Tf 26.9152 0 Td [ (http\072\057\057) -4.00423 (www\056socr\056umich\056edu\057) -4.01894 (projects\057) ] TJ -26.9152 -11.9559 Td [ (3d\055) -50.0039 (cell\055) -50.0015 (morphometry\057) -4.01404 (data\056html) ] TJ /R27 9.9626 Tf 174.386 0 Td (\056) Tj /R15 11.9552 Tf -174.386 -40.0191 Td [ (1\056) -249.989 (Intr) 18.0157 (oduction) ] TJ /R17 9.9626 Tf 11.9551 -20.3129 Td [ (Morphology) -376.986 (of) -376.993 (a) -377 (cell) -376.991 (nucleus) -377.016 (and) -376.991 (its) -377.016 (compartments) -376.991 (is) ] TJ -11.9551 -11.9563 Td [ (re) 15.0098 (gulated) -522.991 (by) -521.982 (comple) 14.9975 (x) -523.006 (biological) -523.011 (m) 0.99003 (echanisms) -522.981 (related) -523.006 (to) ] TJ T* [ (cell) -269.989 (dif) 24.986 (ferentiation\054) -276.005 (de) 25.0154 (v) 14.9828 (elopment\054) -275.018 (proliferation\054) -275.018 (and) -271.009 (disease) ] TJ T* [ (\13314\054) -229.991 (34\054) -229.989 (37\135\056) -302.998 (Changes) -230.016 (in) -229.989 (nuclear) -230 (morphology) -229.991 (are) -230.011 (associated) ] TJ T* [ (with) -232.998 (reor) 17.9921 (g) 4.98446 (anization) -232.995 (of) -233.017 (chromatin) -232.991 (architecture) -233.015 (and) -233.995 (related) -233.015 (to) ] TJ T* [ (altered) -204.983 (functional) -204.995 (properties) -203.986 (such) -205.015 (as) -204.985 (gene) -204.985 (re) 15.0073 (gulation) -204.985 (and) -205.02 (e) 15.0122 (x\055) ] TJ ET Q Q Q q q 1 1 1 rg /a0 gs 48.406 786.422 515.188 -52.699 re f q /s5 gs /x6 Do Q q /s7 gs /x8 Do Q q /s9 gs /x10 Do Q q /s11 gs /x12 Do Q Q Q Q q 1 0 0 1 0 0 cm BT /F1 12 Tf 14.4 TL ET 1 1 1 rg n 270 32 72 14 re f* 0.5 0.5 0.5 rg BT /F2 9 Tf 10.8 TL ET BT 1 0 0 1 297 35 Tm (2385) Tj T* ET Q endstream endobj 14 0 obj << /Filter /FlateDecode /Resources << /ExtGState << /a0 << /CA 1 /ca 1 >> >> /XObject << /x18 15 0 R >> >> /Length 28 /Group << /Type /Group /S /Transparency /CS /DeviceRGB /I true >> /BBox [ 78 746 96 765 ] /Type /XObject /Subtype /Form >> stream x+O4PH/VЯ0Pp 0 endstream endobj 15 0 obj << /Filter /FlateDecode /Resources 16 0 R /Length 107 /Type /XObject /BBox [ 78 746 96 765 ] /Subtype /Form >> stream xe AC̬wʠ =p,?]%+H-
Jc "82w8VSnGW;"
endstream
endobj
16 0 obj
<<
/ExtGState <<
/a0 <<
/CA 1
/ca 1
>>
>>
>>
endobj
17 0 obj
<<
/Filter /FlateDecode
/Resources <<
/ExtGState <<
/a0 <<
/CA 1
/ca 1
>>
>>
/XObject <<
/x15 18 0 R
>>
>>
/Length 28
/Group <<
/Type /Group
/S /Transparency
/CS /DeviceRGB
/I true
>>
/BBox [ 67 752 84 775 ]
/Type /XObject
/Subtype /Form
>>
stream
x+O4PH/VЯ04Up
0
endstream
endobj
18 0 obj
<<
/Filter /FlateDecode
/Resources 19 0 R
/Length 228
/Type /XObject
/BBox [ 67 752 84 775 ]
/Subtype /Form
>>
stream
xeQKn!s ?FPav6R٪TS.
b];15YyR
{7QL.\:Rv/x9l+L7h%1!}i/AI(kz"U&,YO![R hg{3}4/GyYF:!w}Gn+'xJcO9i뽼_-:`
endstream
endobj
19 0 obj
<<
/ExtGState <<
/a0 <<
/CA 1
/ca 1
>>
>>
>>
endobj
20 0 obj
<<
/Filter /FlateDecode
/Resources <<
/ExtGState <<
/a0 <<
/CA 1
/ca 1
>>
>>
/XObject <<
/x24 21 0 R
>>
>>
/Length 28
/Group <<
/Type /Group
/S /Transparency
/CS /DeviceRGB
/I true
>>
/BBox [ 112 751 500 772 ]
/Type /XObject
/Subtype /Form
>>
stream
x+O4PH/VЯ02Qp
0
endstream
endobj
21 0 obj
<<
/Filter /FlateDecode
/Resources 22 0 R
/Length 56490
/Type /XObject
/BBox [ 112 751 500 772 ]
/Subtype /Form
>>
stream
xtIJ5*|^~x?P9)<<ҥ+kh4}/?>]漿վ]Z Ǭ57W'b~?Kwk6:>rAニxeG1k-/LfߗA̺(egk5>
=KO1{Vux}Ol|_s؟|*>5=k|*a5x}On :97~1s7rX {|>IQQo6|'\#x_ڽC}M7(췀(N
سW#^Ň}|zblnB'\o=r;$s:z-
V3+έ昵 WD/nl ;q"3Pg휅\3C`k7760c9-Cȸ